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LOC110121390 VISTA enhancer hs1537 [ Homo sapiens (human) ]

Gene ID: 110121390, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110121390
Gene description
VISTA enhancer hs1537
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents a conserved genomic element that can function as an enhancer. It can activate a Hsp68 promoter coupled to a LacZ reporter gene in embryonic forebrain of transgenic mice. A subregion associated with the OCT4 and NANOG transcription factors was also shown to be an active enhancer by ChIP-STARR-seq in naive human embryonic stem cells. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC110121390 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (55351447..55352813)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (55554547..55555913)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (53018678..53020044)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1929 Neighboring gene RNA, 5S ribosomal pseudogene 459 Neighboring gene NANOG hESC enhancer GRCh37_chr18:52881645-52882231 Neighboring gene Sharpr-MPRA regulatory region 5538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9473 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:52936433-52937632 Neighboring gene transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9474 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:53017604-53018299 Neighboring gene VISTA enhancer hs376 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:53106079-53106856 Neighboring gene TCF4 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:53155630-53156322 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:53176779-53177297 Neighboring gene microRNA 4529 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:53249412-53250006 Neighboring gene transcription factor 4 repeat instability region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13360 Neighboring gene uncharacterized LOC105372126

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VISTA Enhancer Browser--a database of tissue-specific human enhancers. Visel A, et al. Nucleic Acids Res, 2007 Jan. PMID 17130149, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • OCT4-NANOG hESC enhancer GRCh37_chr18:53018931-53019770

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054004.1 

    Range
    101..1467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    55351447..55352813
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    55554547..55555913
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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