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LOC110121210 VISTA enhancer hs1809 [ Homo sapiens (human) ]

Gene ID: 110121210, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110121210
Gene description
VISTA enhancer hs1809
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents a conserved genomic element that can function as an enhancer. It can activate a Hsp68 promoter coupled to a LacZ reporter gene in embryonic forebrain, hindbrain, midbrain and neural tube of transgenic mice. A subregion associated with the OCT4 and NANOG transcription factors was also shown to be an active enhancer by ChIP-STARR-seq in naive human embryonic stem cells. [provided by RefSeq, Nov 2022]
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Genomic context

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Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (122327474..122331024)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (123643430..123646984)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (121967528..121971078)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 37 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:121924115-121924720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:121951480-121951992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:121951993-121952505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:121955253-121955783 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:121956930-121957784 Neighboring gene FEZF1 antisense RNA 1 Neighboring gene FEZ family zinc finger 1 Neighboring gene calcium dependent secretion activator 2 Neighboring gene NANOG hESC enhancer GRCh37_chr7:122088873-122089630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122167222-122167722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122167723-122168223 Neighboring gene uncharacterized LOC105375481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26564 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:122319235-122319791 Neighboring gene ribosomal protein S26 pseudogene 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VISTA Enhancer Browser--a database of tissue-specific human enhancers. Visel A, et al. Nucleic Acids Res, 2007 Jan. PMID 17130149, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • OCT4-NANOG hESC enhancer GRCh37_chr7:121969026-121969690

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053826.1 

    Range
    101..3651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    122327474..122331024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    123643430..123646984
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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