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LOC110120763 VISTA enhancer hs764 [ Homo sapiens (human) ]

Gene ID: 110120763, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110120763
Gene description
VISTA enhancer hs764
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents a conserved genomic element that can function as an enhancer. It can activate a Hsp68 promoter coupled to a LacZ reporter gene in hindbrain and neural tube of transgenic mice. An overlapping subregion associated with the NANOG transcription factor was also shown to be an active enhancer by ChIP-STARR-seq in naive human embryonic stem cells. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC110120763 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (63199548..63200451)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (63078032..63078935)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (63665219..63666122)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1739 Neighboring gene MPRA-validated peak269 silencer Neighboring gene long intergenic non-protein coding RNA 466 Neighboring gene uncharacterized LOC105378770 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:63663717-63664472 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:63664473-63665227 Neighboring gene RNA, 5S ribosomal pseudogene 49 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:63727542 Neighboring gene ribosomal protein SA pseudogene 65 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:63751744-63752272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:63752273-63752802 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:63764905-63765721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:63788679-63789368 Neighboring gene FOXD3 antisense RNA 1 Neighboring gene forkhead box D3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VISTA Enhancer Browser--a database of tissue-specific human enhancers. Visel A, et al. Nucleic Acids Res, 2007 Jan. PMID 17130149, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • NANOG hESC enhancer GRCh37_chr1:63665301-63665802

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053388.1 

    Range
    101..1004
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    63199548..63200451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    63078032..63078935
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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