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Pygb brain glycogen phosphorylase [ Mus musculus (house mouse) ]

Gene ID: 110078, updated on 14-Nov-2024

Summary

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Official Symbol
Pygbprovided by MGI
Official Full Name
brain glycogen phosphorylaseprovided by MGI
Primary source
MGI:MGI:97828
See related
Ensembl:ENSMUSG00000033059 AllianceGenome:MGI:97828
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables glycogen phosphorylase activity. Involved in glycogen catabolic process. Predicted to be located in axon. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; nervous system; sensory organ; and urinary system. Orthologous to human PYGB (glycogen phosphorylase B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart adult (RPKM 143.6), bladder adult (RPKM 120.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Pygb in Genome Data Viewer
Location:
2 G3; 2 74.74 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150628716..150673668)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150786796..150831748)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2053 Neighboring gene STARR-positive B cell enhancer ABC_E1604 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 6 Neighboring gene predicted gene, 30141 Neighboring gene STARR-positive B cell enhancer ABC_E11166 Neighboring gene predicted gene, 57834 Neighboring gene STARR-seq mESC enhancer starr_06017 Neighboring gene abhydrolase domain containing 12 Neighboring gene predicted gene, 23598 Neighboring gene predicted gene, 54124

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glycogenolysis Is Crucial for Astrocytic Glycogen Accumulation and Brain Damage after Reperfusion in Ischemic Stroke. Cai Y, et al. iScience, 2020 May 22. PMID 32446205, Free PMC Article
  2. Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes. Müller MS, et al. Glia, 2015 Jan. PMID 25130497
  3. Organization and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2). Nanda N, et al. Arch Biochem Biophys, 1999 Jun 1. PMID 10334875
  4. The pituitary hormones arginine vasopressin-neurophysin II and oxytocin-neurophysin I show close linkage with interleukin-1 on mouse chromosome 2. Marini JC, et al. Genomics, 1993 Jan. PMID 8432536
  5. Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively. Glaser T, et al. Genomics, 1989 Oct. PMID 2575583

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36329

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables glycogen phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycogen phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycogen phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables maltodextrin phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables organic cyclic compound binding ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycogen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycogen phosphorylase, brain form
NP_722476.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153781.1 → NP_722476.1  glycogen phosphorylase, brain form

    See identical proteins and their annotated locations for NP_722476.1

    Status: PROVISIONAL

    Source sequence(s)
    BC035283
    Consensus CDS
    CCDS16862.1
    UniProtKB/Swiss-Prot
    Q8CI94, Q8K283
    UniProtKB/TrEMBL
    Q3TFQ8, Q3UGT5, Q3UYH9, Q3V3U0
    Related
    ENSMUSP00000035743.8, ENSMUST00000045441.8
    Conserved Domains (2) summary
    cd04300
    Location:29 → 828
    GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...
    TIGR02093
    Location:32 → 828
    P_ylase; glycogen/starch/alpha-glucan phosphorylases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    150628716..150673668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CI94.3 GenPept UniProtKB/Swiss-Prot:Q8CI94

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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