Mcf2 mcf.2 transforming sequence [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mcf2provided by MGI
Official Full Name: mcf.2 transforming sequenceprovided by MGI
Primary source: MGI:MGI:96932
See related: Ensembl:ENSMUSG00000031139 AllianceGenome:MGI:96932
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dbl; Mcf-2; B230117G22Rik
Summary: Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within cellular response to leukemia inhibitory factor and dendrite development. Predicted to be active in cytoplasm. Predicted to be extrinsic component of membrane. Is expressed in femur; fibula; and tibia. Orthologous to human MCF2 (MCF.2 cell line derived transforming sequence). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 1.2), cortex adult (RPKM 0.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A6; X 33.5 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (59101316..59224546, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (60055956..60179184, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Msf2 variant molecule containing an altered SEC14 protein module displays enhanced translocation to the plasma membrane and cell transforming potential.Msf2 expression of this variant in mouse brain suggests that it can be implicated in brain development.
Title: Identification of a novel mouse Dbl proto-oncogene splice variant: evidence that SEC14 domain is involved in GEF activity regulation.
Phosphoinositide 3-kinase C2beta regulates RhoA and the actin cytoskeleton through an interaction with Dbl
Title: Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl.
Dbl is regulated by hamartin through association with ezrin.
Title: The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin.
onco-Dbl has a potentially important, previously unreported, capacity to dramatically alter epithelial cell migration, replication, polarization and differentiation and to induce vascularization of an epithelial tissue
Title: Induction of epithelial mesenchimal transition and vasculogenesis in the lenses of Dbl oncogene transgenic mice.
Results suggest a mechanism by which proto-Dbl and its effector pathways are regulated by Galpha(13)-mediated signals.
Title: Galpha13 regulation of proto-Dbl signaling.
Lacking a palindromic dblGATA-binding site, lineage-ablated bone marrow progenitor cells from delta dblGATA mice respond to ex vivo culture by overuse of a second more proximal promoter, generating enough GATA-1 to support eosinophilopoiesis.
Title: Eosinophils from lineage-ablated Delta dblGATA bone marrow progenitors: the dblGATA enhancer in the promoter of GATA-1 is not essential for differentiation ex vivo.
Hsc70 attenuates Dbl activity by maintaining an inactive conformation in which the amino terminus is "folded over" the catalytic DH-PH domain
Title: Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70).
provides fundamental data on the structure of Mcf-2, which regulates a variety of cellular signaling pathways
Title: Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene.
Regulation of proto-Dbl by intracellular membrane targeting and protein stability (proto-oncogene Dbl)
Title: Regulation of proto-Dbl by intracellular membrane targeting and protein stability.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

MHAa53g6.seq (e-PCR)
- UniSTS:125201

NoName (e-PCR)
- UniSTS:234065

px-37d10 (e-PCR)
- UniSTS:257676

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proto-oncogene DBL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289730.2 → NP_001276659.1 proto-oncogene DBL isoform 3

Status: VALIDATED

Source sequence(s)

AK032122, AK045424, AL670778, AL671984

Consensus CDS

CCDS81129.1

UniProtKB/TrEMBL

A2AET8, Q7TNJ5

Related

ENSMUSP00000033478.5, ENSMUST00000033478.5

Conserved Domains (5) summary

cd00160
Location:511 → 688

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam00169
Location:727 → 823

PH; PH domain

cl02488
Location:225 → 416

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl15787
Location:20 → 85

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl17171
Location:695 → 826

PH-like; Pleckstrin homology-like domain
NM_001289731.2 → NP_001276660.1 proto-oncogene DBL isoform 1

Status: VALIDATED

Source sequence(s)

AL670778, AL671984, AL929279

Consensus CDS

CCDS72384.1

UniProtKB/TrEMBL

A2AEU1, Q8BLE2

Related

ENSMUSP00000067075.5, ENSMUST00000063507.11

Conserved Domains (5) summary

smart00516
Location:128 → 268

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:678 → 855

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam00169
Location:877 → 990

PH; PH domain

cl02488
Location:408 → 599

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:862 → 993

PH-like; Pleckstrin homology-like domain
NM_001358998.1 → NP_001345927.1 proto-oncogene DBL isoform 4

Status: VALIDATED

Source sequence(s)

AL670778, AL671984, AL929279

UniProtKB/TrEMBL

Q7TNJ5

Conserved Domains (4) summary

cd00160
Location:472 → 649

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam13716
Location:19 → 73

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:186 → 377

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:656 → 787

PH-like; Pleckstrin homology-like domain
NM_001358999.1 → NP_001345928.1 proto-oncogene DBL isoform 5

Status: VALIDATED

Source sequence(s)

AL670778, AL671984, AL929279

UniProtKB/TrEMBL

Q99N72

Conserved Domains (4) summary

cd00160
Location:456 → 633

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam13716
Location:19 → 73

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:186 → 377

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:640 → 771

PH-like; Pleckstrin homology-like domain
NM_001359000.1 → NP_001345929.1 proto-oncogene DBL isoform 6

Status: VALIDATED

Source sequence(s)

AL670778, AL671984, AL929279

UniProtKB/TrEMBL

Q99N72

Conserved Domains (4) summary

cd00160
Location:455 → 632

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:219 → 376

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl15787
Location:20 → 85

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl17171
Location:639 → 770

PH-like; Pleckstrin homology-like domain
NM_001359001.1 → NP_001345930.1 proto-oncogene DBL isoform 7

Status: VALIDATED

Source sequence(s)

AL670778, AL671984, AL929279

UniProtKB/TrEMBL

Q99N72

Conserved Domains (4) summary

cd00160
Location:416 → 593

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam13716
Location:19 → 73

CRAL_TRIO_2; Divergent CRAL/TRIO domain

cl02488
Location:180 → 337

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:600 → 731

PH-like; Pleckstrin homology-like domain
NM_133197.5 → NP_573460.2 proto-oncogene DBL isoform 2

See identical proteins and their annotated locations for NP_573460.2

Status: VALIDATED

Source sequence(s)

AK032122, AK045424, AL670778, AL671984

Consensus CDS

CCDS30160.1

UniProtKB/TrEMBL

Q8C067, Q99N72

Related

ENSMUSP00000099070.4, ENSMUST00000101531.10

Conserved Domains (5) summary

cd00160
Location:495 → 672

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam00169
Location:711 → 807

PH; PH domain

cl02488
Location:225 → 416

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl15787
Location:20 → 85

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl17171
Location:679 → 810

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

59101316..59224546 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251191.2 → XP_030107051.1 proto-oncogene DBL isoform X7

UniProtKB/TrEMBL

A2AEU1, Q8BLE2

Conserved Domains (4) summary

cd00160
Location:615 → 792

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:363 → 520

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl15787
Location:128 → 239

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl17171
Location:799 → 930

PH-like; Pleckstrin homology-like domain
XM_030251192.2 → XP_030107052.1 proto-oncogene DBL isoform X8

UniProtKB/TrEMBL

A2AEU1, Q8BLE2

Conserved Domains (4) summary

cd00160
Location:599 → 776

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:363 → 520

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl15787
Location:128 → 239

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl17171
Location:783 → 914

PH-like; Pleckstrin homology-like domain
XM_006527743.4 → XP_006527806.1 proto-oncogene DBL isoform X5

UniProtKB/TrEMBL

A2AEU1, Q8BLE2

Conserved Domains (4) summary

cd00160
Location:639 → 816

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:369 → 560

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl15787
Location:128 → 239

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl17171
Location:823 → 954

PH-like; Pleckstrin homology-like domain
XM_017318343.2 → XP_017173832.1 proto-oncogene DBL isoform X2

UniProtKB/TrEMBL

A2AEU1, Q8BLE2

Conserved Domains (4) summary

cd00160
Location:655 → 832

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:369 → 560

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl15787
Location:128 → 239

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl17171
Location:839 → 970

PH-like; Pleckstrin homology-like domain
XM_017318345.2 → XP_017173834.1 proto-oncogene DBL isoform X6

UniProtKB/TrEMBL

A2AEU1, Q8BLE2

Conserved Domains (4) summary

smart00516
Location:128 → 268

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:638 → 815

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:402 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:822 → 953

PH-like; Pleckstrin homology-like domain
XM_017318344.2 → XP_017173833.1 proto-oncogene DBL isoform X3

UniProtKB/TrEMBL

A2AEU1, Q8BLE2

Conserved Domains (4) summary

smart00516
Location:128 → 268

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:654 → 831

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:402 → 559

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:838 → 969

PH-like; Pleckstrin homology-like domain
XM_036161775.1 → XP_036017668.1 proto-oncogene DBL isoform X4

UniProtKB/TrEMBL

A2AEU1, Q8BLE2

Conserved Domains (4) summary

smart00516
Location:128 → 268

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:694 → 841

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:408 → 599

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:833 → 967

PH-like; Pleckstrin homology-like domain
XM_006527750.4 → XP_006527813.1 proto-oncogene DBL isoform X1

UniProtKB/TrEMBL

A2AEU1, Q8BLE2

Conserved Domains (4) summary

smart00516
Location:128 → 268

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:694 → 871

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:408 → 599

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:878 → 1009

PH-like; Pleckstrin homology-like domain
XM_036161777.1 → XP_036017670.1 proto-oncogene DBL isoform X11

UniProtKB/TrEMBL

Q99N72

Conserved Domains (3) summary

cd00160
Location:456 → 603

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:186 → 377

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:595 → 729

PH-like; Pleckstrin homology-like domain
XM_017318347.2 → XP_017173836.1 proto-oncogene DBL isoform X9

UniProtKB/TrEMBL

Q7TNJ5

Conserved Domains (4) summary

cd00160
Location:471 → 648

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:219 → 376

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl15787
Location:20 → 85

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl17171
Location:655 → 786

PH-like; Pleckstrin homology-like domain
XM_036161776.1 → XP_036017669.1 proto-oncogene DBL isoform X10

UniProtKB/TrEMBL

Q99N72

Conserved Domains (4) summary

cd00160
Location:495 → 642

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl02488
Location:225 → 416

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl15787
Location:20 → 85

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

cl17171
Location:634 → 768

PH-like; Pleckstrin homology-like domain