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TOP2A DNA topoisomerase II alpha [ Bos indicus (zebu cattle) ]

Gene ID: 109574397, updated on 14-Mar-2024

Summary

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Gene symbol
TOP2A
Gene description
DNA topoisomerase II alpha
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos indicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See TOP2A in Genome Data Viewer
Location:
chromosome: 19
Exon count:
34
Annotation release Status Assembly Chr Location
100 current Bos_indicus_1.0 (GCF_000247795.1) 19 NC_032668.1 (41891448..41917743, complement)

Chromosome 19 - NC_032668.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27a-like Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene uncharacterized LOC109573984 Neighboring gene insulin like growth factor binding protein 4 Neighboring gene tensin 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032668.1 Chromosome 19 Reference Bos_indicus_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A preliminary sketch of horn cancer transcriptome in Indian zebu cattle. Tripathi AK, et al. Gene, 2012 Feb 1. PMID 22134011
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in resolution of meiotic recombination intermediates IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sister chromatid segregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA topoisomerase 2-alpha
Names
topoisomerase (DNA) II alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bos indicus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_indicus_1.0 Primary Assembly

Genomic

  1. NC_032668.1 Reference Bos_indicus_1.0 Primary Assembly

    Range
    41891448..41917743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019982412.1 → XP_019837971.1  DNA topoisomerase 2-alpha

    UniProtKB/TrEMBL
    A0A6P5DL09
    Conserved Domains (1) summary
    PTZ00108
    Location:25 → 1325
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  2. XM_019982411.1 → XP_019837970.1  DNA topoisomerase 2-alpha

    UniProtKB/TrEMBL
    A0A6P5DL09
    Conserved Domains (1) summary
    PTZ00108
    Location:25 → 1325
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
Nucleotide Protein
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