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C11orf58 chromosome 11 open reading frame 58 [ Homo sapiens (human) ]

Gene ID: 10944, updated on 5-Mar-2024

Summary

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Official Symbol
C11orf58provided by HGNC
Official Full Name
chromosome 11 open reading frame 58provided by HGNC
Primary source
HGNC:HGNC:16990
See related
Ensembl:ENSG00000110696 MIM:619625; AllianceGenome:HGNC:16990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMAP; IMAGE145052
Expression
Ubiquitous expression in thyroid (RPKM 25.7), endometrium (RPKM 22.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11p15.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (16738647..16758340)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (16836026..16855719)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (16760194..16779887)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 6 Neighboring gene MPRA-validated peak1218 silencer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:16628669-16629170 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:16629171-16629670 Neighboring gene uncharacterized LOC105376571 Neighboring gene RNA, 7SL, cytoplasmic 188, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16691079-16691580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16691581-16692082 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16699888-16700416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16700417-16700944 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:16730412-16730912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:16730913-16731413 Neighboring gene MPRA-validated peak1219 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16800297-16801020 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:16801021-16801743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16802139-16802833 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16802834-16803527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16803848-16804825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16812092-16812592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16812593-16813093 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:16823697-16824896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16836605-16837105 Neighboring gene pleckstrin homology domain containing A7 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:16875052-16875264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4481 Neighboring gene VISTA enhancer hs2096 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:16918881-16919566 Neighboring gene RN7SK pseudogene 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16946213-16946824 Neighboring gene small nucleolar RNA, C/D box 147

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel genes expressed in the chick otocyst during development: identification using differential display of RNA. Gong TW, et al. Int J Dev Neurosci, 1997 Jul. PMID 9263035
  2. Splicing Regulator p54(nrb) /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. Hu Z, et al. Hepatology, 2020 Aug. PMID 31815296
  3. Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding. Huang X, et al. J Biol Chem, 2019 Aug 16. PMID 31248990, Free PMC Article
  4. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. Tao WA, et al. Nat Methods, 2005 Aug. PMID 16094384
  5. KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Kumar A, et al. Cell Rep, 2022 May 10. PMID 35545047, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117265, DKFZp686N0232

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
small acidic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014267.6 → NP_055082.1  small acidic protein

    See identical proteins and their annotated locations for NP_055082.1

    Status: VALIDATED

    Source sequence(s)
    AC026639
    Consensus CDS
    CCDS7822.1
    UniProtKB/Swiss-Prot
    B2RD28, O00193
    Related
    ENSP00000228136.4, ENST00000228136.9
    Conserved Domains (1) summary
    pfam15477
    Location:27 → 103
    SMAP; Small acidic protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    16738647..16758340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017143.3 → XP_016872632.1  small acidic protein isoform X1

    Conserved Domains (1) summary
    pfam15477
    Location:1 → 59
    SMAP; Small acidic protein family

  2. XM_047426310.1 → XP_047282266.1  small acidic protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    16836026..16855719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001142705.1: Suppressed sequence

    Description
    NM_001142705.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00193.1 GenPept UniProtKB/Swiss-Prot:O00193

Gene LinkOut

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