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Cdcp1 CUB domain containing protein 1 [ Mus musculus (house mouse) ]

Gene ID: 109332, updated on 17-Aug-2024

Summary

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Official Symbol
Cdcp1provided by MGI
Official Full Name
CUB domain containing protein 1provided by MGI
Primary source
MGI:MGI:2442010
See related
Ensembl:ENSMUSG00000035498 AllianceGenome:MGI:2442010
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030022E12Rik; E030027H19Rik
Summary
Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adenohypophysis; alimentary system; bladder fundus; respiratory system; and sensory organ. Orthologous to human CDCP1 (CUB domain containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 12.9), colon adult (RPKM 10.2) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Cdcp1 in Genome Data Viewer
Location:
9 F4; 9 73.92 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122999870..123045175, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123170805..123216110, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 3, member b Neighboring gene predicted gene, 23323 Neighboring gene STARR-seq mESC enhancer starr_25558 Neighboring gene STARR-seq mESC enhancer starr_25559 Neighboring gene STARR-seq mESC enhancer starr_25560 Neighboring gene transmembrane protein 158 Neighboring gene STARR-seq mESC enhancer starr_25561 Neighboring gene sterol carrier protein 2, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis. Zhang L, et al. JCI Insight, 2022 Sep 22. PMID 35951427, Free PMC Article
  2. CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease. Lun Y, et al. J Immunol, 2021 Jun 15. PMID 34099547, Free PMC Article
  3. CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression. Saponaro M, et al. Sci Rep, 2023 Jan 2. PMID 36593286, Free PMC Article
  4. CD318 is a ligand for CD6. Enyindah-Asonye G, et al. Proc Natl Acad Sci U S A, 2017 Aug 15. PMID 28760953, Free PMC Article
  5. Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. Spassov DS, et al. Cancer Res, 2013 Feb 1. PMID 23243018, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.
    Title: CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.
  2. CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis.
    Title: CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis.
  3. CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease.
    Title: CDCP1 on Dendritic Cells Contributes to the Development of a Model of Kawasaki Disease.
  4. CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.
    Title: CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.
  5. Results indicate Cdcp1 (CD318) as a ligand of T-cell differentiation antigen CD6 (CD6) and a potential target for the diagnosis and treatment of autoimmune diseases.
    Title: CD318 is a ligand for CD6.
  6. Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells.
    Title: Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells.
  7. established mechanism for initiation of CDCP1-mediated signaling; demonstrated that processing of surface CDCP1 by extracellular serine proteases is prerequisite for CDCP1-dependent survival of cancer cells during metastasis; preventing cleavage of CDCP1 abrogated survival signaling associated with CDCP1 and induced PARP1 cleavage and PARP1-mediated apoptosis
    Title: Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells.
  8. CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model
    Title: Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CUB domain-containing protein 1
Names
membrane glycoprotein gp140
transmembrane and associated with src kinases

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133974.3 → NP_598735.2  CUB domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_598735.2

    Status: PROVISIONAL

    Source sequence(s)
    AC134248
    Consensus CDS
    CCDS23657.1
    UniProtKB/Swiss-Prot
    Q5U462, Q810J0, Q921M9
    UniProtKB/TrEMBL
    Q05D42
    Related
    ENSMUSP00000042057.8, ENSMUST00000039229.8
    Conserved Domains (1) summary
    cl00049
    Location:225 → 297
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    122999870..123045175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511921.3 → XP_006511984.1  CUB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    Q05D42
    Conserved Domains (1) summary
    cl00049
    Location:224 → 296
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

  2. XM_006511922.3 → XP_006511985.1  CUB domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    cl00049
    Location:166 → 238
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U462.1 GenPept UniProtKB/Swiss-Prot:Q5U462

Gene LinkOut

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