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R3hdm4 R3H domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 109284, updated on 28-Oct-2024

Summary

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Official Symbol
R3hdm4provided by MGI
Official Full Name
R3H domain containing 4provided by MGI
Primary source
MGI:MGI:1924814
See related
Ensembl:ENSMUSG00000035781 AllianceGenome:MGI:1924814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C030046I01Rik
Summary
Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. Is expressed in cortical plate. Orthologous to human R3HDM4 (R3H domain containing 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in stomach adult (RPKM 133.4), colon adult (RPKM 121.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See R3hdm4 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79745886..79752764, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79910052..79916930, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 16 Neighboring gene STARR-positive B cell enhancer ABC_E2946 Neighboring gene STARR-positive B cell enhancer ABC_E252 Neighboring gene predicted gene, 24019 Neighboring gene KISS1 receptor Neighboring gene STARR-positive B cell enhancer ABC_E6878 Neighboring gene STARR-positive B cell enhancer ABC_E10625 Neighboring gene predicted gene, 40715

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
R3H domain-containing protein 4
Names
R3H domain-containing protein C19orf22 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378997.1 → NP_001365926.1  R3H domain-containing protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC151846
    Conserved Domains (2) summary
    pfam01424
    Location:189 → 248
    R3H; R3H domain
    pfam13902
    Location:50 → 177
    R3H-assoc; R3H-associated N-terminal domain

  2. NM_177994.5 → NP_818775.2  R3H domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_818775.2

    Status: VALIDATED

    Source sequence(s)
    AC151846
    Consensus CDS
    CCDS23997.1
    UniProtKB/Swiss-Prot
    Q4VBF2, Q8BJN1, Q8CGD7, Q8JZZ8
    UniProtKB/TrEMBL
    B2RRK4
    Related
    ENSMUSP00000044570.8, ENSMUST00000045628.15
    Conserved Domains (2) summary
    pfam01424
    Location:183 → 242
    R3H; R3H domain
    pfam13902
    Location:50 → 177
    R3H-assoc; R3H-associated N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79745886..79752764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VBF2.1 GenPept UniProtKB/Swiss-Prot:Q4VBF2

Gene LinkOut

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