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LOC109245080 Fgf15 5' regulatory region [ Mus musculus (house mouse) ]

Gene ID: 109245080, updated on 9-Aug-2024

Summary

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Gene symbol
LOC109245080
Gene description
Fgf15 5' regulatory region
Gene type
biological region
Feature type(s)
protein_bind
regulatory: enhancer, promoter, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366765
Summary
This region encompasses the 5' regulatory region of the fibroblast growth factor 15 gene. It includes a conserved enhancer element that drives expression of a reporter transgene in neural tissue. Activity of this region is mediated by sequence elements that recognize vitamin D receptor and GLI family zinc finger proteins. [provided by RefSeq, Dec 2016]
Orthologs
human all
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Genomic context

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See LOC109245080 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144446694..144450354)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144892957..144896617)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Fgf3 proximal promoter region Neighboring gene fibroblast growth factor 3 Neighboring gene STARR-seq mESC enhancer starr_20549 Neighboring gene Fgf4 promoter region Neighboring gene Fgf4 3' enhancer Neighboring gene fibroblast growth factor 4 Neighboring gene Fgf15 upstream enhancer Neighboring gene predicted gene, 26793 Neighboring gene STARR-seq mESC enhancer starr_20554 Neighboring gene fibroblast growth factor 15 Neighboring gene predicted gene, 39119 Neighboring gene brain cytoplasmic RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of bile acid synthesis by fat-soluble vitamins A and D. Schmidt DR, et al. J Biol Chem, 2010 May 7. PMID 20233723, Free PMC Article
  2. Expression of Fgf15 is regulated by both activator and repressor forms of Gli2 in vitro. Komada M, et al. Biochem Biophys Res Commun, 2008 May 2. PMID 18279667
  3. A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. McWhirter JR, et al. Development, 1997 Sep. PMID 9310317
  4. Analysis of Fibroblast growth factor 15 cis-elements reveals two conserved enhancers which are closely related to cardiac outflow tract development. Saitsu H, et al. Mech Dev, 2006 Sep. PMID 16930954
  5. Direct Interactions Between Gli3, Wnt8b, and Fgfs Underlie Patterning of the Dorsal Telencephalon. Hasenpusch-Theil K, et al. Cereb Cortex, 2017 Feb 1. PMID 26656997

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Other Names

  • regulatory region 366765

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052549.1 

    Range
    101..3761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    144446694..144450354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version