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Lrrc39 leucine rich repeat containing 39 [ Mus musculus (house mouse) ]

Gene ID: 109245, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrc39provided by MGI
Official Full Name
leucine rich repeat containing 39provided by MGI
Primary source
MGI:MGI:1924557
See related
Ensembl:ENSMUSG00000027961 AllianceGenome:MGI:1924557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myomasp; 2010005E21Rik; 9430028I06Rik
Summary
Predicted to be involved in intracellular signal transduction. Predicted to be located in M band. Orthologous to human LRRC39 (leucine rich repeat containing 39). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart adult (RPKM 10.7), mammary gland adult (RPKM 2.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrc39 in Genome Data Viewer
Location:
3 G1; 3 50.39 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116356610..116376793)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116562954..116583144)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene dihydrolipoamide branched chain transacylase E2 Neighboring gene ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) pseudogene Neighboring gene splicing factor, arginine/serine-rich pseudogene Neighboring gene STARR-seq mESC enhancer starr_08780 Neighboring gene tRNA methyltransferase 13 Neighboring gene STARR-positive B cell enhancer ABC_E1630 Neighboring gene SAS-6 centriolar assembly protein Neighboring gene STARR-seq mESC enhancer starr_08781 Neighboring gene STARR-seq mESC enhancer starr_08784 Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene STARR-seq mESC enhancer starr_08785 Neighboring gene STARR-positive B cell enhancer ABC_E3464 Neighboring gene STARR-seq mESC enhancer starr_08789 Neighboring gene microRNA 3473h

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing. Will RD, et al. Circ Res, 2010 Nov 12. PMID 20847312
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reveal myomasp/LRRC39 as a previously unrecognized component of an M-band-associated signaling pathway that regulates cardiomyocyte gene expression in response to biomechanical stress.
    Title: Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in M band IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 39
Names
myosin-interacting M-band-associated stress-responsive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379629.1 → NP_001366558.1  leucine-rich repeat-containing protein 39 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC025622, AC131038
    Conserved Domains (2) summary
    COG4886
    Location:19 → 286
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:85 → 107
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_001379630.1 → NP_001366559.1  leucine-rich repeat-containing protein 39 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC025622, AC131038
    Conserved Domains (2) summary
    COG4886
    Location:90 → 275
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:74 → 96
    LRR_RI; leucine-rich repeat [structural motif]

  3. NM_027321.4 → NP_081597.1  leucine-rich repeat-containing protein 39 isoform 1

    See identical proteins and their annotated locations for NP_081597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC025622
    UniProtKB/TrEMBL
    Q9D8D7
    Related
    ENSMUST00000203327.2
    Conserved Domains (3) summary
    sd00031
    Location:108 → 130
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:129 → 170
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:84 → 141
    LRR_8; Leucine rich repeat

  4. NM_175413.4 → NP_780622.1  leucine-rich repeat-containing protein 39 isoform 2

    See identical proteins and their annotated locations for NP_780622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform 2.
    Source sequence(s)
    AC025622, AC131038
    Consensus CDS
    CCDS17788.1
    UniProtKB/Swiss-Prot
    Q8BGI7
    UniProtKB/TrEMBL
    Q0VDT4
    Related
    ENSMUSP00000029573.6, ENSMUST00000029573.8
    Conserved Domains (3) summary
    cd00116
    Location:72 → 257
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:85 → 107
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:222 → 280
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    116356610..116376793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500862.5 → XP_006500925.1  leucine-rich repeat-containing protein 39 isoform X1

    Conserved Domains (2) summary
    COG4886
    Location:37 → 275
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:85 → 107
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. XR_003954272.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGI7.1 GenPept UniProtKB/Swiss-Prot:Q8BGI7

Gene LinkOut

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