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Supt3 SPT3, SAGA and STAGA complex component [ Mus musculus (house mouse) ]

Gene ID: 109115, updated on 30-Apr-2024

Summary

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Official Symbol
Supt3provided by MGI
Official Full Name
SPT3, SAGA and STAGA complex componentprovided by MGI
Primary source
MGI:MGI:1923723
See related
Ensembl:ENSMUSG00000038954 AllianceGenome:MGI:1923723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPT3; SPT3L; Supt3h; 2310066G22Rik
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in histone H3 acetylation and histone deubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of SAGA complex and transcription factor TFTC complex. Is expressed in bladder; ovary; testis; urethra of female; and urethra of male. Orthologous to human SUPT3H (SPT3 homolog, SAGA and STAGA complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 2.7), CNS E11.5 (RPKM 1.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Supt3 in Genome Data Viewer
Location:
17 B3; 17 21.56 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45088005..45430181)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (44777118..45119294)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 5 Neighboring gene STARR-seq mESC enhancer starr_42608 Neighboring gene STARR-positive B cell enhancer ABC_E5611 Neighboring gene STARR-seq mESC enhancer starr_42609 Neighboring gene STARR-seq mESC enhancer starr_42610 Neighboring gene STARR-seq mESC enhancer starr_42611 Neighboring gene STARR-seq mESC enhancer starr_42612 Neighboring gene runt related transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_42613 Neighboring gene VISTA enhancer mm924 Neighboring gene runt related transcription factor 2, opposite strand 3 Neighboring gene STARR-seq mESC enhancer starr_42614 Neighboring gene VISTA enhancer mm657 Neighboring gene Runx2 P2 promoter Neighboring gene Runx2 P1 promoter region Neighboring gene RIKEN cDNA 4930564C03 gene Neighboring gene predicted gene, 52304 Neighboring gene STARR-seq mESC enhancer starr_42615 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45256870-45256979 Neighboring gene STARR-seq mESC enhancer starr_42616 Neighboring gene predicted gene, 35097 Neighboring gene coiled-coil domain containing 94 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. Zelin E, et al. Mol Cell, 2012 Nov 9. PMID 23022381, Free PMC Article
  2. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Nagy Z, et al. Oncogene, 2007 Aug 13. PMID 17694077
  3. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. Schiltz RL, et al. J Biol Chem, 1999 Jan 15. PMID 9880483
  4. Histone-like TAFs within the PCAF histone acetylase complex. Ogryzko VV, et al. Cell, 1998 Jul 10. PMID 9674425
  5. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. Brand M, et al. EMBO J, 2001 Jun 15. PMID 11406595, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
transcription initiation protein SPT3 homolog
Names
suppressor of Ty 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178652.3 → NP_848767.1  transcription initiation protein SPT3 homolog

    See identical proteins and their annotated locations for NP_848767.1

    Status: VALIDATED

    Source sequence(s)
    AK075916, AL672242, CX210559
    Consensus CDS
    CCDS37625.1
    UniProtKB/TrEMBL
    Q8BU36, Q8BVY4, Q8BWQ2
    Related
    ENSMUSP00000050783.8, ENSMUST00000050630.14
    Conserved Domains (2) summary
    pfam02269
    Location:24 → 116
    TFIID-18kDa; Transcription initiation factor IID, 18kD subunit
    cl02176
    Location:332 → 351
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RNA

  1. NR_158206.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK075916, AL672242, BG067596, CX210559
    Related
    ENSMUST00000127798.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45088005..45430181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523477.3 → XP_006523540.1  transcription initiation protein SPT3 homolog isoform X2

    See identical proteins and their annotated locations for XP_006523540.1

    UniProtKB/TrEMBL
    B0QZW4
    Conserved Domains (1) summary
    pfam02269
    Location:24 → 116
    TFIID-18kDa; Transcription initiation factor IID, 18kD subunit

  2. XM_030249446.1 → XP_030105306.1  transcription initiation protein SPT3 homolog isoform X4

    UniProtKB/TrEMBL
    B0QZW4
    Conserved Domains (2) summary
    cl02174
    Location:1 → 30
    TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl02176
    Location:246 → 265
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  3. XM_030249447.1 → XP_030105307.1  transcription initiation protein SPT3 homolog isoform X3

    Conserved Domains (2) summary
    cl02174
    Location:1 → 30
    TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl02176
    Location:246 → 265
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  4. XM_006523478.5 → XP_006523541.1  transcription initiation protein SPT3 homolog isoform X2

    See identical proteins and their annotated locations for XP_006523541.1

    UniProtKB/TrEMBL
    B0QZW4
    Related
    ENSMUSP00000120197.2, ENSMUST00000129416.2
    Conserved Domains (1) summary
    pfam02269
    Location:24 → 116
    TFIID-18kDa; Transcription initiation factor IID, 18kD subunit

  5. XM_006523479.5 → XP_006523542.2  transcription initiation protein SPT3 homolog isoform X3

    Conserved Domains (2) summary
    cl02174
    Location:1 → 30
    TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl02176
    Location:246 → 265
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  6. XM_030249445.1 → XP_030105305.1  transcription initiation protein SPT3 homolog isoform X1

    Conserved Domains (1) summary
    cl02174
    Location:1 → 30
    TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001357320.1: Suppressed sequence

    Description
    NM_001357320.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version

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