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LOC109113859 FGF1 promoter B [ Homo sapiens (human) ]

Gene ID: 109113859, updated on 10-Oct-2023

Summary

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Gene symbol
LOC109113859
Gene description
FGF1 promoter B
Gene type
biological region
Feature type(s)
protein_bind
regulatory: enhancer, promoter
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents the alternate B promoter of the fibroblast growth factor 1 (FGF1) gene. This promoter drives expression in the brain and is regulated by binding of regulatory factor X and transcription factor 4 (Tcf4/E2-2). [provided by RefSeq, Nov 2016]
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Genomic context

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See LOC109113859 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (142686036..142686899)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (143217276..143218139)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (142065601..142066464)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S12 pseudogene 10 Neighboring gene FGF1 promoter D Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene FGF1 promoter C Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:142024170-142025369 Neighboring gene Sharpr-MPRA regulatory region 3450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142039508-142040008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142040009-142040509 Neighboring gene fibroblast growth factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047003-142047511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047512-142048019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142049247-142049746 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142052360-142052880 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:142064129-142064998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142150581-142151416 Neighboring gene long intergenic non-protein coding RNA 1844 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142176991-142177492 Neighboring gene Rho GTPase activating protein 26 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16477 Neighboring gene ARHGAP26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142242364-142242980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142242981-142243597 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142243598-142244214 Neighboring gene Sharpr-MPRA regulatory region 7053

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of FGF1B Promoter and FGF1 Are Involved in Cardiogenesis Through the Signaling of PKC, but Not MAPK. Lin HY, et al. Stem Cells Dev, 2015 Dec 15. PMID 26414172
  2. The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK-3 activities. Kao CY, et al. J Neurochem, 2013 Jul. PMID 23647222
  3. Isolation of neural stem/progenitor cells by using EGF/FGF1 and FGF1B promoter-driven green fluorescence from embryonic and adult mouse brains. Lee DC, et al. Mol Cell Neurosci, 2009 Jul. PMID 19409495
  4. Brain-specific 1B promoter of FGF1 gene facilitates the isolation of neural stem/progenitor cells with self-renewal and multipotent capacities. Hsu YC, et al. Dev Dyn, 2009 Feb. PMID 18855895
  5. Transcriptional activation of fibroblast growth factor 1.B promoter is mediated through an 18-base pair cis-acting element. Ray SK, et al. J Biol Chem, 1997 Mar 14. PMID 9054460

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • F1B promoter
  • FGF-1.B promoter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052017.1 

    Range
    101..964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    142686036..142686899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    143217276..143218139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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