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Rnf169 ring finger protein 169 [ Mus musculus (house mouse) ]

Gene ID: 108937, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf169provided by MGI
Official Full Name
ring finger protein 169provided by MGI
Primary source
MGI:MGI:1920257
See related
Ensembl:ENSMUSG00000058761 AllianceGenome:MGI:1920257
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900057K09Rik
Summary
Predicted to enable modification-dependent protein binding activity; nucleosome binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in double-strand break repair via homologous recombination and negative regulation of double-strand break repair. Predicted to be located in cytosol; nuclear body; and nucleolus. Predicted to be active in nucleus and site of double-strand break. Is expressed in nervous system and retina. Orthologous to human RNF169 (ring finger protein 169). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 1.9), CNS E11.5 (RPKM 1.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf169 in Genome Data Viewer
Location:
7 E2; 7 54.22 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99569461..99630537, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99920254..99981330, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene signal peptidase complex subunit 2 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E1347 Neighboring gene X-ray radiation resistance associated 1 Neighboring gene predicted gene, 38405 Neighboring gene predicted gene 5115 Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19665 Neighboring gene SET translocation pseudogene Neighboring gene chordin-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-modified histone reader activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-modified histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
located_in site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF169
Names
RING-type E3 ubiquitin transferase RNF169
NP_780597.2
XP_006507248.1
XP_006507250.1
XP_006507251.1
XP_030097842.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175388.3 → NP_780597.2  E3 ubiquitin-protein ligase RNF169

    See identical proteins and their annotated locations for NP_780597.2

    Status: PROVISIONAL

    Source sequence(s)
    AC113298
    Consensus CDS
    CCDS52322.1
    UniProtKB/Swiss-Prot
    E9Q7F2, Q69Z47
    Related
    ENSMUSP00000079631.4, ENSMUST00000080817.6
    Conserved Domains (1) summary
    pfam05142
    Location:76 → 143
    DUF702; Domain of unknown function (DUF702)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99569461..99630537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507185.4 → XP_006507248.1  E3 ubiquitin-protein ligase RNF169 isoform X1

    Conserved Domains (1) summary
    cd16551
    Location:90 → 127
    RING-HC_RNF169; RING finger, HC subclass, found in RING finger protein 169 (RNF169) and similar proteins

  2. XM_030241982.2 → XP_030097842.1  E3 ubiquitin-protein ligase RNF169 isoform X2

  3. XM_006507187.5 → XP_006507250.1  E3 ubiquitin-protein ligase RNF169 isoform X2

  4. XM_006507188.5 → XP_006507251.1  E3 ubiquitin-protein ligase RNF169 isoform X3

    Conserved Domains (2) summary
    cd00162
    Location:91 → 126
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl17238
    Location:90 → 127
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q7F2.1 GenPept UniProtKB/Swiss-Prot:E9Q7F2

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