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Calr4 calreticulin 4 [ Mus musculus (house mouse) ]

Gene ID: 108802, updated on 2-Nov-2024

Summary

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Official Symbol
Calr4provided by MGI
Official Full Name
calreticulin 4provided by MGI
Primary source
MGI:MGI:2140435
See related
Ensembl:ENSMUSG00000028558 AllianceGenome:MGI:2140435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933403L16Rik
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human CALR4P (calreticulin 4, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Calr4 in Genome Data Viewer
Location:
4 C7; 4 51.1 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109075610..109112176)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109218413..109254979)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 9 Neighboring gene STARR-positive B cell enhancer ABC_E6198 Neighboring gene STARR-seq mESC enhancer starr_11065 Neighboring gene predicted gene, 52703 Neighboring gene STARR-positive B cell enhancer ABC_E11807 Neighboring gene predicted gene, 46867 Neighboring gene predicted gene, 40225 Neighboring gene STARR-positive B cell enhancer ABC_E2703 Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene predicted gene, 52753 Neighboring gene predicted gene, 52702

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors. Dey S, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21933956, Free PMC Article
  2. Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development. Díaz Del Moral S, et al. Front Cell Dev Biol, 2021. PMID 34368133, Free PMC Article
  3. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Ansarullah, et al. Nature, 2021 Feb. PMID 33505018
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calreticulin 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033226.4 → NP_001028398.1  calreticulin 4 isoform b precursor

    See identical proteins and their annotated locations for NP_001028398.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK139540, AK163350, BG083829
    Consensus CDS
    CCDS18461.1
    UniProtKB/TrEMBL
    Q3TQS0
    Related
    ENSMUSP00000030285.8, ENSMUST00000030285.8
    Conserved Domains (1) summary
    pfam00262
    Location:13 → 318
    Calreticulin; Calreticulin family

  2. NM_001285895.1 → NP_001272824.1  calreticulin 4 isoform a precursor

    See identical proteins and their annotated locations for NP_001272824.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK139540, AL627103, BG083829, JN255799
    UniProtKB/TrEMBL
    G5CPP0
    Conserved Domains (1) summary
    pfam00262
    Location:28 → 337
    Calreticulin; Calreticulin family

  3. NM_001285896.1 → NP_001272825.1  calreticulin 4 isoform c

    See identical proteins and their annotated locations for NP_001272825.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AK077094, AK139540, BG083829
    Consensus CDS
    CCDS71441.1
    UniProtKB/TrEMBL
    A2A8Z3
    Related
    ENSMUSP00000102240.2, ENSMUST00000106629.8
    Conserved Domains (1) summary
    pfam00262
    Location:1 → 211
    Calreticulin; Calreticulin family

  4. NM_001285897.1 → NP_001272826.1  calreticulin 4 isoform c

    See identical proteins and their annotated locations for NP_001272826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AK077094, AK139540, AL627103, BG083829
    Consensus CDS
    CCDS71441.1
    UniProtKB/TrEMBL
    A2A8Z3
    Related
    ENSMUSP00000102239.2, ENSMUST00000106628.8
    Conserved Domains (1) summary
    pfam00262
    Location:1 → 211
    Calreticulin; Calreticulin family

  5. NM_001285898.1 → NP_001272827.1  calreticulin 4 isoform c

    See identical proteins and their annotated locations for NP_001272827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AK077094, AK139540, AL627103, BG083829
    Consensus CDS
    CCDS71441.1
    UniProtKB/TrEMBL
    A2A8Z3
    Related
    ENSMUSP00000102242.3, ENSMUST00000106631.9
    Conserved Domains (1) summary
    pfam00262
    Location:1 → 211
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    109075610..109112176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163569.1 → XP_036019462.1  calreticulin 4 isoform X2

    Conserved Domains (1) summary
    pfam00262
    Location:7 → 308
    Calreticulin; Calreticulin family

  2. XM_017319911.3 → XP_017175400.2  calreticulin 4 isoform X1

    Conserved Domains (1) summary
    pfam00262
    Location:103 → 403
    Calreticulin; Calreticulin family

  3. XM_030253072.2 → XP_030108932.1  calreticulin 4 isoform X3

    Conserved Domains (1) summary
    pfam00262
    Location:44 → 141
    Calreticulin; Calreticulin family
Nucleotide Protein Strain
Heading Accession and Version

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