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rasgrp3.S RAS guanyl releasing protein 3 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 108717828, updated on 4-Nov-2024

Summary

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Official Symbol
rasgrp3.S
Official Full Name
RAS guanyl releasing protein 3 S homeolog
Primary source
Xenbase:XB-GENE-17335178
Locus tag
XELAEV_18028982mg
See related
EnsemblRapid:ENSXLAG00005005818 AllianceGenome:Xenbase:XB-GENE-17335178
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rasgrp3.S in Genome Data Viewer
Location:
chromosome: 5S
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5S NC_054380.1 (38173685..38237195)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5S NC_030733.1 (38068946..38113198)

Chromosome 5S - NC_054380.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat protein 27-like Neighboring gene latent transforming growth factor beta binding protein 1 S homeolog Neighboring gene protein FAM98A Neighboring gene uncharacterized LOC121394190

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
ras guanyl-releasing protein 3
Names
RAS guanyl releasing protein 3 (calcium and DAG-regulated) S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    38173685..38237195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041564423.1 → XP_041420357.1  ras guanyl-releasing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A1L8G260, A0A974CWP2, A0A974HH80
    Conserved Domains (4) summary
    cd06224
    Location:11 → 126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148 → 384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam13499
    Location:427 → 477
    EF-hand_7; EF-hand domain pair
    cd20862
    Location:487 → 545
    C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins

  2. XM_041564422.1 → XP_041420356.1  ras guanyl-releasing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A1L8G260, A0A974CWP2, A0A974HH80
    Related
    ENSXLAP00005017333.1, ENSXLAT00005017629.1
    Conserved Domains (4) summary
    cd06224
    Location:11 → 126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148 → 384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam13499
    Location:427 → 477
    EF-hand_7; EF-hand domain pair
    cd20862
    Location:487 → 545
    C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins

  3. XM_041564424.1 → XP_041420358.1  ras guanyl-releasing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8J1KUC8, A0A974CWP2
    Related
    ENSXLAP00005017317.1, ENSXLAT00005017613.1
    Conserved Domains (4) summary
    cd06224
    Location:11 → 126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00109
    Location:484 → 533
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00147
    Location:148 → 374
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00051
    Location:414 → 465
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein Strain
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