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rasa2.L RAS p21 protein activator 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 108717133, updated on 4-Nov-2024

Summary

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Official Symbol
rasa2.L
Official Full Name
RAS p21 protein activator 2 L homeolog
Primary source
Xenbase:XB-GENE-6488091
Locus tag
XELAEV_18027917mg
See related
EnsemblRapid:ENSXLAG00005015512 AllianceGenome:Xenbase:XB-GENE-6488091
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to act upstream of or within intracellular signal transduction and negative regulation of Ras protein signal transduction. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RASA2 (RAS p21 protein activator 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rasa2.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
25
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (139184511..139252567)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (128113802..128182032)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 14 L homeolog Neighboring gene zinc finger and BTB domain containing 38 L homeolog Neighboring gene sex hormone-binding globulin Neighboring gene uncharacterized LOC108717135

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    139184511..139252567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018263950.2 → XP_018119439.1  ras GTPase-activating protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A1L8GBH7, A0A974CWC0
    Related
    ENSXLAP00005045584.1, ENSXLAT00005046683.1

  2. XM_041563484.1 → XP_041419418.1  ras GTPase-activating protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8J1KRN2
    Related
    ENSXLAP00005045575.1, ENSXLAT00005046674.1
    Conserved Domains (5) summary
    cd04010
    Location:113 → 255
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:1 → 101
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05394
    Location:264 → 535
    RasGAP_RASA2; Ras-GTPase Activating Domain of RASA2
    cd13370
    Location:532 → 664
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02465
    Location:649 → 683
    BTK; BTK motif
Nucleotide Protein Strain
Heading Accession and Version

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