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prkar2a.L protein kinase, cAMP-dependent, regulatory subunit type II alpha L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 108714672, updated on 4-Nov-2024

Summary

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Official Symbol
prkar2a.L
Official Full Name
protein kinase, cAMP-dependent, regulatory subunit type II alpha L homeolog
Primary source
Xenbase:XB-GENE-17338310
Locus tag
XELAEV_18024017mg
See related
EnsemblRapid:ENSXLAG00005026758 AllianceGenome:Xenbase:XB-GENE-17338310
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Predicted to act upstream of or within negative regulation of cAMP-dependent protein kinase activity. Predicted to be located in plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See prkar2a.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (136811710..136860837, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (131574832..131624392, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene transfer RNA phenylalanine (anticodon GAA) Neighboring gene inositol hexaphosphate kinase 2 L homeolog Neighboring gene uncharacterized LOC121402863 Neighboring gene solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A catalytic subunit binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase type II-alpha regulatory subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    136811710..136860837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018259088.2 → XP_018114577.1  cAMP-dependent protein kinase type II-alpha regulatory subunit

    UniProtKB/TrEMBL
    A0A1L8GPR3, A0A974HQ57
    Related
    ENSXLAP00005079649.1, ENSXLAT00005081240.1
Nucleotide Protein Strain
Heading Accession and Version

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