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inppl1a.L inositol polyphosphate phosphatase-like 1a L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 108708768, updated on 4-Nov-2024

Summary

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Official Symbol
inppl1a.L
Official Full Name
inositol polyphosphate phosphatase-like 1a L homeolog
Primary source
Xenbase:XB-GENE-6487464
Locus tag
XELAEV_18013913mg
See related
EnsemblRapid:ENSXLAG00005029865 AllianceGenome:Xenbase:XB-GENE-6487464
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ship2; inppl1; inppl1.L
Summary
Predicted to enable inositol-polyphosphate 5-phosphatase activity and phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. Predicted to act upstream of or within several processes, including negative regulation of insulin-like growth factor receptor signaling pathway; phosphatidylinositol dephosphorylation; and regulation of immune response. Predicted to be located in several cellular components, including filopodium; lamellipodium; and nuclear speck. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Orthologous to human INPPL1 (inositol polyphosphate phosphatase like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See inppl1a.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
28
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (179732012..179762477, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (172107760..172136817, complement)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene ClpB family mitochondrial disaggregase L homeolog Neighboring gene paired like homeobox 2A S homeolog Neighboring gene transmembrane O-methyltransferase homolog Neighboring gene folate receptor alpha L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables inositol-polyphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Names
inositol polyphosphate phosphatase like 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    179732012..179762477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018247799.2 → XP_018103288.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

    UniProtKB/TrEMBL
    A0A1L8HJJ3, A0A974DQN2
    Related
    ENSXLAP00005089926.1, ENSXLAT00005091602.1
Nucleotide Protein Strain
Heading Accession and Version

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