U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CEACAM7 CEA cell adhesion molecule 7 [ Homo sapiens (human) ]

Gene ID: 1087, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
CEACAM7provided by HGNC
Official Full Name
CEA cell adhesion molecule 7provided by HGNC
Primary source
HGNC:HGNC:1819
See related
Ensembl:ENSG00000007306 MIM:619160; AllianceGenome:HGNC:1819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGM2
Summary
This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Restricted expression toward colon (RPKM 448.6) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CEACAM7 in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41673303..41688270, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44492598..44507564, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42177231..42192199, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372405 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10670 Neighboring gene CEA cell adhesion molecule 5 Neighboring gene uncharacterized LOC112268252 Neighboring gene CEA cell adhesion molecule 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients. Pérez-García F, et al. J Microbiol Immunol Infect, 2022 Jun. PMID 34657826
  2. Structure of the N-terminal dimerization domain of CEACAM7. Bonsor DA, et al. Acta Crystallogr F Struct Biol Commun, 2015 Sep. PMID 26323304, Free PMC Article
  3. Distribution of carcinoembryonic antigen-related cellular adhesion molecules in human gingiva. Huynh-Torlakovic H, et al. Eur J Oral Sci, 2012 Oct. PMID 22984996
  4. Dynamic expression of CEACAM7 in precursor lesions of gastric carcinoma and its prognostic value in combination with CEA. Zhou J, et al. World J Surg Oncol, 2011 Dec 23. PMID 22195770, Free PMC Article
  5. CEACAM-7: a predictive marker for rectal cancer recurrence. Messick CA, et al. Surgery, 2010 May. PMID 20004437

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients.
    Title: CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients.
  2. CEACAM7 expression is significantly upregulated in human masticatory mucosa during wound healing
    Title: Human gingiva transcriptome during wound healing.
  3. crystal structure of the N-terminal dimerization domain of CEACAM has been determined at 1.47 A resolution
    Title: Structure of the N-terminal dimerization domain of CEACAM7.
  4. High CEACAM7 is associated with gastric carcinoma.
    Title: Dynamic expression of CEACAM7 in precursor lesions of gastric carcinoma and its prognostic value in combination with CEA.
  5. CEACAM-7 expression is significantly decreased in rectal cancer; a potential tumor marker
    Title: CEACAM-7: a predictive marker for rectal cancer recurrence.
  6. CGM2 RT-PCR assay provides no specific prognostic information and cannot be used as a decision criterion for adjuvant therapy after colorectal cancer surgery.
    Title: Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 7
Names
carcinoembryonic antigen CGM2
carcinoembryonic antigen gene family member 2
carcinoembryonic antigen related cell adhesion molecule 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291485.2 → NP_001278414.1  carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein

    See identical proteins and their annotated locations for NP_001278414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC243960, AK292213
    Consensus CDS
    CCDS12583.1
    UniProtKB/Swiss-Prot
    A8K848, O15148, O15149, Q0VAC1, Q13983, Q14002, Q9UPJ2
    UniProtKB/TrEMBL
    B4DKM4
    Related
    ENSP00000385932.1, ENST00000401731.6
    Conserved Domains (2) summary
    cd05774
    Location:38 → 141
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:147 → 234
    Ig; Immunoglobulin domain

  2. NM_006890.5 → NP_008821.2  carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein

    See identical proteins and their annotated locations for NP_008821.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC243960, BC121132, DC345133
    Consensus CDS
    CCDS12583.1
    UniProtKB/Swiss-Prot
    A8K848, O15148, O15149, Q0VAC1, Q13983, Q14002, Q9UPJ2
    UniProtKB/TrEMBL
    B4DKM4
    Related
    ENSP00000006724.3, ENST00000006724.7
    Conserved Domains (2) summary
    cd05774
    Location:38 → 141
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:147 → 234
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41673303..41688270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187620.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    4498..8698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44492598..44507564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14002.2 GenPept UniProtKB/Swiss-Prot:Q14002

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous