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plec.S plectin S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 108695482, updated on 4-Nov-2024

Summary

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Official Symbol
plec.S
Official Full Name
plectin S homeolog
Primary source
Xenbase:XB-GENE-17337945
Locus tag
XELAEV_18034125mg
See related
EnsemblRapid:ENSXLAG00005012302 AllianceGenome:Xenbase:XB-GENE-17337945
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hd1; pcn; ebs1; ebso; pltn; plec1; plec1b; plectin
Summary
Predicted to enable actin binding activity; ankyrin binding activity; and cadherin binding activity. Predicted to be a structural constituent of cytoskeleton and structural constituent of muscle. Predicted to act upstream of or within hemidesmosome assembly; intermediate filament cytoskeleton organization; and wound healing. Predicted to be located in several cellular components, including focal adhesion; hemidesmosome; and sarcolemma. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Q; epidermolysis bullosa simplex; epidermolysis bullosa simplex Ogna type; and epidermolysis bullosa simplex with muscular dystrophy. Orthologous to human PLEC (plectin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See plec.S in Genome Data Viewer
Location:
chromosome: 6S
Exon count:
42
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (136469462..136591733)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (127613164..127736099)

Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108695486 Neighboring gene fucolectin-1 Neighboring gene 5S ribosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene cytochrome P450 2B4-like S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables ankyrin binding IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of muscle IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hemidesmosome assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within wound healing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in hemidesmosome IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
plectin S homeolog; plectin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    136469462..136591733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041568052.1 → XP_041423986.1  plectin isoform X3

    UniProtKB/TrEMBL
    A0A8J1L364
    Related
    ENSXLAP00005036113.1, ENSXLAT00005037013.1
    Conserved Domains (11) summary
    PTZ00121
    Location:1374 → 2178
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:558 → 651
    SPEC; Spectrin repeats
    smart00250
    Location:3131 → 3167
    PLEC; Plectin repeat
    COG0419
    Location:997 → 1576
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:653 → 831
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1818 → 2651
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4075 → 4114
    Plectin; Plectin repeat
    pfam17902
    Location:828 → 894
    SH3_10; SH3 domain
    pfam18373
    Location:929 → 1006
    Spectrin_like; Spectrin like domain
    cd21188
    Location:67 → 183
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:196 → 301
    CH_SF; calponin homology (CH) domain superfamily

  2. XM_041568054.1 → XP_041423988.1  plectin isoform X4

    UniProtKB/TrEMBL
    A0A8J1L379
    Conserved Domains (11) summary
    PTZ00121
    Location:1362 → 2166
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:546 → 639
    SPEC; Spectrin repeats
    smart00250
    Location:3119 → 3155
    PLEC; Plectin repeat
    COG0419
    Location:985 → 1564
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:641 → 819
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1806 → 2639
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4063 → 4102
    Plectin; Plectin repeat
    pfam17902
    Location:816 → 882
    SH3_10; SH3 domain
    pfam18373
    Location:917 → 994
    Spectrin_like; Spectrin like domain
    cd21188
    Location:67 → 171
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:184 → 289
    CH_SF; calponin homology (CH) domain superfamily

  3. XM_018224013.2 → XP_018079502.1  plectin isoform X3

    UniProtKB/TrEMBL
    A0A8J1L364
    Conserved Domains (11) summary
    PTZ00121
    Location:1374 → 2178
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:558 → 651
    SPEC; Spectrin repeats
    smart00250
    Location:3131 → 3167
    PLEC; Plectin repeat
    COG0419
    Location:997 → 1576
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:653 → 831
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1818 → 2651
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4075 → 4114
    Plectin; Plectin repeat
    pfam17902
    Location:828 → 894
    SH3_10; SH3 domain
    pfam18373
    Location:929 → 1006
    Spectrin_like; Spectrin like domain
    cd21188
    Location:67 → 183
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:196 → 301
    CH_SF; calponin homology (CH) domain superfamily

  4. XM_041568059.1 → XP_041423993.1  plectin isoform X9

    UniProtKB/TrEMBL
    A0A8J1L384
    Related
    ENSXLAP00005036105.1, ENSXLAT00005037005.1
    Conserved Domains (10) summary
    PTZ00121
    Location:1341 → 2145
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:525 → 618
    SPEC; Spectrin repeats
    smart00250
    Location:3098 → 3134
    PLEC; Plectin repeat
    COG0419
    Location:964 → 1543
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:620 → 798
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1785 → 2618
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4042 → 4081
    Plectin; Plectin repeat
    pfam17902
    Location:795 → 861
    SH3_10; SH3 domain
    pfam18373
    Location:896 → 973
    Spectrin_like; Spectrin like domain
    cl00030
    Location:20 → 159
    CH_SF; calponin homology (CH) domain superfamily

  5. XM_041568061.1 → XP_041423995.1  plectin isoform X11

    UniProtKB/TrEMBL
    A0A8J1L5X6
    Related
    ENSXLAP00005036099.1, ENSXLAT00005036999.1
    Conserved Domains (11) summary
    PTZ00121
    Location:1326 → 2130
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:510 → 603
    SPEC; Spectrin repeats
    smart00250
    Location:3083 → 3119
    PLEC; Plectin repeat
    COG0419
    Location:949 → 1528
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:605 → 783
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1770 → 2603
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4027 → 4066
    Plectin; Plectin repeat
    pfam17902
    Location:780 → 846
    SH3_10; SH3 domain
    pfam18373
    Location:881 → 958
    Spectrin_like; Spectrin like domain
    cd21188
    Location:19 → 135
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:148 → 253
    CH_SF; calponin homology (CH) domain superfamily

  6. XM_041568050.1 → XP_041423984.1  plectin isoform X1

    UniProtKB/TrEMBL
    A0A8J1L4U2
    Conserved Domains (8) summary
    PTZ00121
    Location:2164 → 2981
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:1361 → 1454
    SPEC; Spectrin repeats
    smart00250
    Location:5144 → 5181
    PLEC; Plectin repeat
    COG0419
    Location:1800 → 2379
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG5069
    Location:866 → 1100
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:1456 → 1634
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02102
    Location:5 → 114
    S10_plectin; Plectin/S10 domain
    cl17036
    Location:1647 → 1691
    SH3; Src Homology 3 domain superfamily

  7. XM_041568051.1 → XP_041423985.1  plectin isoform X2

    UniProtKB/TrEMBL
    A0A8J1L5W5
    Related
    ENSXLAP00005036109.1, ENSXLAT00005037009.1
    Conserved Domains (8) summary
    PTZ00121
    Location:2152 → 2969
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:1349 → 1442
    SPEC; Spectrin repeats
    smart00250
    Location:5132 → 5169
    PLEC; Plectin repeat
    COG0419
    Location:1788 → 2367
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG5069
    Location:866 → 1088
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:1444 → 1622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02102
    Location:5 → 114
    S10_plectin; Plectin/S10 domain
    cl17036
    Location:1635 → 1679
    SH3; Src Homology 3 domain superfamily

  8. XM_041568060.1 → XP_041423994.1  plectin isoform X10

    UniProtKB/TrEMBL
    A0A8J1L4V5
    Conserved Domains (11) summary
    PTZ00121
    Location:1329 → 2133
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:513 → 606
    SPEC; Spectrin repeats
    smart00250
    Location:3086 → 3122
    PLEC; Plectin repeat
    COG0419
    Location:952 → 1531
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:608 → 786
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1773 → 2606
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4030 → 4069
    Plectin; Plectin repeat
    pfam17902
    Location:783 → 849
    SH3_10; SH3 domain
    pfam18373
    Location:884 → 961
    Spectrin_like; Spectrin like domain
    cd21188
    Location:22 → 138
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:151 → 256
    CH_SF; calponin homology (CH) domain superfamily

  9. XM_041568055.1 → XP_041423989.1  plectin isoform X5

    UniProtKB/TrEMBL
    A0A8J1L4U9
    Conserved Domains (11) summary
    PTZ00121
    Location:1359 → 2163
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:543 → 636
    SPEC; Spectrin repeats
    smart00250
    Location:3116 → 3152
    PLEC; Plectin repeat
    COG0419
    Location:982 → 1561
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:638 → 816
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1803 → 2636
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4060 → 4099
    Plectin; Plectin repeat
    pfam17902
    Location:813 → 879
    SH3_10; SH3 domain
    pfam18373
    Location:914 → 991
    Spectrin_like; Spectrin like domain
    cd21188
    Location:52 → 168
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:181 → 286
    CH_SF; calponin homology (CH) domain superfamily

  10. XM_041568057.1 → XP_041423991.1  plectin isoform X7

    UniProtKB/TrEMBL
    A0A8J1L369
    Related
    ENSXLAP00005036078.1, ENSXLAT00005036978.1
    Conserved Domains (11) summary
    PTZ00121
    Location:1347 → 2151
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:531 → 624
    SPEC; Spectrin repeats
    smart00250
    Location:3104 → 3140
    PLEC; Plectin repeat
    COG0419
    Location:970 → 1549
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:626 → 804
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1791 → 2624
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4048 → 4087
    Plectin; Plectin repeat
    pfam17902
    Location:801 → 867
    SH3_10; SH3 domain
    pfam18373
    Location:902 → 979
    Spectrin_like; Spectrin like domain
    cd21188
    Location:52 → 156
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:169 → 274
    CH_SF; calponin homology (CH) domain superfamily

  11. XM_041568056.1 → XP_041423990.1  plectin isoform X6

    UniProtKB/TrEMBL
    A0A8J1L5X0
    Conserved Domains (11) summary
    PTZ00121
    Location:1353 → 2157
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:537 → 630
    SPEC; Spectrin repeats
    smart00250
    Location:3110 → 3146
    PLEC; Plectin repeat
    COG0419
    Location:976 → 1555
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:632 → 810
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1797 → 2630
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4054 → 4093
    Plectin; Plectin repeat
    pfam17902
    Location:807 → 873
    SH3_10; SH3 domain
    pfam18373
    Location:908 → 985
    Spectrin_like; Spectrin like domain
    cd21188
    Location:46 → 162
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:175 → 280
    CH_SF; calponin homology (CH) domain superfamily

  12. XM_041568058.1 → XP_041423992.1  plectin isoform X8

    UniProtKB/TrEMBL
    A0A1L8FU77, A0A974HEP0
    Related
    ENSXLAP00005036066.1, ENSXLAT00005036966.1
    Conserved Domains (11) summary
    PTZ00121
    Location:1341 → 2145
    PTZ00121; MAEBL; Provisional
    smart00150
    Location:525 → 618
    SPEC; Spectrin repeats
    smart00250
    Location:3098 → 3134
    PLEC; Plectin repeat
    COG0419
    Location:964 → 1543
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00176
    Location:620 → 798
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02463
    Location:1785 → 2618
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam00681
    Location:4042 → 4081
    Plectin; Plectin repeat
    pfam17902
    Location:795 → 861
    SH3_10; SH3 domain
    pfam18373
    Location:896 → 973
    Spectrin_like; Spectrin like domain
    cd21188
    Location:46 → 150
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:163 → 268
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein Strain
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