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Rimklb ribosomal modification protein rimK-like family member B [ Mus musculus (house mouse) ]

Gene ID: 108653, updated on 2-Nov-2024

Summary

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Official Symbol
Rimklbprovided by MGI
Official Full Name
ribosomal modification protein rimK-like family member Bprovided by MGI
Primary source
MGI:MGI:1918325
See related
Ensembl:ENSMUSG00000040649 AllianceGenome:MGI:1918325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Naags; 4931417E21Rik; 4933426K21Rik
Summary
Enables N-acetyl-L-aspartate-L-glutamate ligase activity and citrate-L-glutamate ligase activity. Predicted to be involved in protein modification process. Located in cytoplasm. Is expressed in several structures, including central nervous system; eye; genitourinary system; hindlimb phalanx; and tooth. Orthologous to human RIMKLB (ribosomal modification protein rimK like family member B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 16.4), CNS E14 (RPKM 14.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Rimklb in Genome Data Viewer
Location:
6 F1; 6 57.55 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122424255..122464021, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122447296..122487062, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700063H04 gene Neighboring gene VISTA enhancer mm94 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17224 Neighboring gene ribosomal protein S27A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_17225 Neighboring gene STARR-positive B cell enhancer ABC_E10409 Neighboring gene microfibrillar associated protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E1070 Neighboring gene STARR-positive B cell enhancer ABC_E9100 Neighboring gene STARR-positive B cell enhancer mm9_chr6:122484210-122484511 Neighboring gene STARR-positive B cell enhancer ABC_E11336 Neighboring gene STARR-positive B cell enhancer ABC_E3677 Neighboring gene STARR-positive B cell enhancer ABC_E3678 Neighboring gene activation-induced cytidine deaminase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Citrylglutamate synthase deficient male mice are subfertile with impaired histone and transition protein 2 removal in late spermatids. Wang-Eckhardt L, et al. Biochem J, 2022 May 13. PMID 35419597
  2. Rimklb mutation causes male infertility in mice. Maekura K, et al. Sci Rep, 2021 Feb 25. PMID 33633267, Free PMC Article
  3. NAAG synthetase deficiency has only low influence on pathogenesis in a Canavan disease mouse model. Becker I, et al. J Inherit Metab Dis, 2024 Mar. PMID 38011891
  4. Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase. Collard F, et al. J Biol Chem, 2010 Sep 24. PMID 20657015, Free PMC Article
  5. Molecular characterization of N-acetylaspartylglutamate synthetase. Becker I, et al. J Biol Chem, 2010 Sep 17. PMID 20643647, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rimklb mutation causes male infertility in mice.
    Title: Rimklb mutation causes male infertility in mice.
  2. Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
    Title: Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables N-acetyl-L-aspartate-L-glutamate ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyl-L-aspartate-L-glutamate ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables citrate-L-glutamate ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
beta-citrylglutamate synthase B
Names
N-acetyl-aspartyl-glutamate synthetase B
N-acetyl-aspartylglutamate synthetase B
N-acetylaspartyl-glutamate synthetase B
NAAG synthetase B
beta-citryl-glutamate synthase B
ribosomal protein S6 modification-like protein B
NP_081940.1
XP_030110915.1
XP_030110916.1
XP_030110917.1
XP_030110918.1
XP_036021620.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027664.1 → NP_081940.1  beta-citrylglutamate synthase B

    See identical proteins and their annotated locations for NP_081940.1

    Status: VALIDATED

    Source sequence(s)
    AK039398, AK173135, BB616179, BC052078
    Consensus CDS
    CCDS39622.1
    UniProtKB/Swiss-Prot
    Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
    Related
    ENSMUSP00000064467.7, ENSMUST00000068242.9
    Conserved Domains (1) summary
    cl17255
    Location:8 → 303
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    122424255..122464021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255058.2 → XP_030110918.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
    Conserved Domains (1) summary
    cl17255
    Location:8 → 303
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  2. XM_036165727.1 → XP_036021620.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
    Conserved Domains (1) summary
    cl17255
    Location:8 → 303
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  3. XM_030255055.2 → XP_030110915.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
    Conserved Domains (1) summary
    cl17255
    Location:8 → 303
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  4. XM_030255056.2 → XP_030110916.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
    Conserved Domains (1) summary
    cl17255
    Location:8 → 303
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  5. XM_030255057.2 → XP_030110917.1  beta-citrylglutamate synthase B isoform X1

    UniProtKB/Swiss-Prot
    Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
    Conserved Domains (1) summary
    cl17255
    Location:8 → 303
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

RNA

  1. XR_003956144.2 RNA Sequence

  2. XR_003956143.2 RNA Sequence

  3. XR_003956145.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WS1.1 GenPept UniProtKB/Swiss-Prot:Q80WS1

Gene LinkOut

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