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Vav2r3 Vav2R3 erythroid cis-regulatory module [ Mus musculus (house mouse) ]

Gene ID: 108511961, updated on 8-Feb-2024

Summary

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Gene symbol
Vav2r3
Gene description
Vav2R3 erythroid cis-regulatory module
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366724
Summary
This genomic element is located in an intron of the Vav2 (vav 2 oncogene) gene on chromosome 2. It was predicted to be a cis-regulatory module (preCRM) based on the presence of conserved consensus binding motifs for the essential erythroid transcription factor GATA1, and on distinctive alignment patterns that yielded a positive regulatory potential score. It was validated as a functional enhancer by reporter assays in transiently transfected human K562 erythroleukemia cells. [provided by RefSeq, Aug 2016]
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Genomic context

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See Vav2r3 in Genome Data Viewer
Location:
2 A3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27233980..27234216)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27343968..27344204)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dopamine beta hydroxylase Neighboring gene sarcosine dehydrogenase Neighboring gene vav 2 oncogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27159262-27159371 Neighboring gene Vav2R10 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04000 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27269900-27270101 Neighboring gene STARR-seq mESC enhancer starr_04002 Neighboring gene Vav2R7 erythroid cis-regulatory module Neighboring gene Vav2R5 erythroid cis-regulatory module Neighboring gene bromodomain containing 3, opposite strand Neighboring gene microRNA 7578 Neighboring gene bromodomain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Experimental validation of predicted mammalian erythroid cis-regulatory modules. Wang H, et al. Genome Res, 2006 Dec. PMID 17038566, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • Vav2R3 erythroid enhancer
  • Vav2R3 preCRM
  • regulatory region 366724

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051413.1 

    Range
    101..337
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    27233980..27234216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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