PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [Manis javanica (Malayan pangolin)] - Gene

Summary

Gene symbol: PFKFB3
Gene description: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Gene type: protein coding
RefSeq status: MODEL
Organism: Manis javanica
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	YNU_ManJav_2.0 (GCF_014570535.1)	Unplaced Scaffold	NW_023435931.1 (5222307..5254035, complement)
100	previous assembly	ManJav1.0 (GCF_001685135.1)	Unplaced Scaffold	NW_016538167.1 (20202..99762)

NW_023435931.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 6-phosphofructo-2-kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables fructose-2,6-bisphosphate 2-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fructose 2,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fructose metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference YNU_ManJav_2.0 Primary Assembly

Genomic

NW_023435931.1 Reference YNU_ManJav_2.0 Primary Assembly

Range

5222307..5254035 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_037001433.1 → XP_036857328.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X6

Conserved Domains (2) summary

pfam00300
Location:249 → 435

His_Phos_1; Histidine phosphatase superfamily (branch 1)

pfam01591
Location:26 → 246

6PF2K; 6-phosphofructo-2-kinase
XM_037001397.1 → XP_036857292.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X1

Conserved Domains (2) summary

pfam00300
Location:129 → 315

His_Phos_1; Histidine phosphatase superfamily (branch 1)

cl17190
Location:2 → 126

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_037001409.1 → XP_036857304.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2

Conserved Domains (2) summary

pfam00300
Location:129 → 315

His_Phos_1; Histidine phosphatase superfamily (branch 1)

cl17190
Location:2 → 126

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_037001423.1 → XP_036857318.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4

Conserved Domains (2) summary

pfam00300
Location:129 → 315

His_Phos_1; Histidine phosphatase superfamily (branch 1)

cl17190
Location:2 → 126

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_037001431.1 → XP_036857326.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X5

Conserved Domains (2) summary

pfam00300
Location:129 → 315

His_Phos_1; Histidine phosphatase superfamily (branch 1)

cl17190
Location:2 → 126

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_037001418.1 → XP_036857313.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3

Conserved Domains (2) summary

pfam00300
Location:129 → 315

His_Phos_1; Histidine phosphatase superfamily (branch 1)

cl17190
Location:2 → 126

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...