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PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Manis javanica (Malayan pangolin) ]

Gene ID: 108400388, updated on 14-Mar-2024

Summary

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Gene symbol
PIK3CB
Gene description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Gene type
protein coding
RefSeq status
MODEL
Organism
Manis javanica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
Orthologs
human mouse all
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Genomic context

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See PIK3CB in Genome Data Viewer
Location:
chromosome: Un
Exon count:
27
Annotation release Status Assembly Chr Location
101 current YNU_ManJav_2.0 (GCF_014570535.1) Unplaced Scaffold NW_023436134.1 (2524188..2772284)
100 previous assembly ManJav1.0 (GCF_001685135.1) Unplaced Scaffold NW_016527832.1 (12827..217023)

NW_023436134.1Genomic Context describing neighboring genes Neighboring gene forkhead box L2 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC118967127 Neighboring gene Fas apoptotic inhibitory molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference YNU_ManJav_2.0 Primary Assembly

Genomic

  1. NW_023436134.1 Reference YNU_ManJav_2.0 Primary Assembly

    Range
    2524188..2772284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036991630.1 → XP_036847525.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    Conserved Domains (6) summary
    cd08693
    Location:324 → 501
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:532 → 702
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:706 → 1066
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:42 → 117
    PI3K_p85B; PI3-kinase family, p85-binding domain
    cl02776
    Location:13 → 65
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. XM_036991629.1 → XP_036847524.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    Conserved Domains (4) summary
    cd08693
    Location:107 → 284
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    cd00872
    Location:315 → 485
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:489 → 849
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    cl02484
    Location:1 → 71
    PI3K_rbd; PI3-kinase family, ras-binding domain
Nucleotide Protein
Heading Accession and Version

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