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Intu inturned planar cell polarity protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 108348166, updated on 2-Nov-2024

Summary

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Symbol
Intuprovided by RGD
Full Name
inturned planar cell polarity proteinprovided by RGD
Primary source
RGD:1309446
See related
EnsemblRapid:ENSRNOG00000010556 AllianceGenome:RGD:1309446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pdzk6
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including cilium assembly; regulation of smoothened signaling pathway; and tongue morphogenesis. Predicted to act upstream of or within several processes, including cilium assembly; hair follicle morphogenesis; and nervous system development. Predicted to be located in ciliary transition zone; microtubule organizing center; and motile cilium. Predicted to be active in cilium and cytoplasm. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy and orofaciodigital syndrome XVII. Orthologous to human INTU (inturned planar cell polarity protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See Intu in Genome Data Viewer
Location:
2q26
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (125528965..125613295)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (123600972..123685331)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (127459089..127521327)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550593 Neighboring gene uncharacterized LOC120100807 Neighboring gene myoneurin, pseudogene 1 Neighboring gene solute carrier family 25 member 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Yang N, et al. Oncogene, 2017 Aug 31. PMID 28459465, Free PMC Article
  2. Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Lundby A, et al. Nat Commun, 2012 Jun 6. PMID 22673903, Free PMC Article
  3. The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells. Yasunaga T, et al. J Cell Biol, 2015 Dec 7. PMID 26644512, Free PMC Article
  4. The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery. Toriyama M, et al. Nat Genet, 2016 Jun. PMID 27158779, Free PMC Article
  5. PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals. Zeng H, et al. Dev Biol, 2010 Mar 15. PMID 20067783

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of planar polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in limb development ISO
Inferred from Sequence Orthology
more info
  
involved_in limb development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural tube development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural tube development ISO
Inferred from Sequence Orthology
more info
  
involved_in non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to organelle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ossification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of ossification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in roof of mouth development IEA
Inferred from Electronic Annotation
more info
  
involved_in roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in spinal cord dorsal/ventral patterning IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spinal cord dorsal/ventral patterning ISO
Inferred from Sequence Orthology
more info
  
involved_in tongue morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tongue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary transition zone IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein inturned
Names
PDZ domain containing 6
PDZ domain-containing protein 6
inturned planar cell polarity effector homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421108.1 → NP_001408037.1  protein inturned

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6II27
    Related
    ENSRNOP00000065417.3, ENSRNOT00000072675.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    125528965..125613295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103628.2 → XP_038959556.1  protein inturned isoform X2

    UniProtKB/Swiss-Prot
    D4ACE5
    Conserved Domains (4) summary
    cd00136
    Location:185 → 248
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    pfam19031
    Location:292 → 437
    Intu_longin_1; First Longin domain of INTU, CCZ1 and HPS4
    pfam19032
    Location:535 → 653
    Intu_longin_2; Intu longin-like domain 2
    pfam19033
    Location:813 → 953
    Intu_longin_3; Intu longin-like domain 3

  2. XM_063281132.1 → XP_063137202.1  protein inturned isoform X4

    Related
    ENSRNOP00000099219.1, ENSRNOT00000149536.1

  3. XM_039103627.2 → XP_038959555.1  protein inturned isoform X1

    UniProtKB/Swiss-Prot
    D4ACE5
    UniProtKB/TrEMBL
    A0A1W2Q6D8
    Related
    ENSRNOP00000076219.2, ENSRNOT00000093581.3
    Conserved Domains (4) summary
    cd00136
    Location:203 → 266
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    pfam19031
    Location:310 → 455
    Intu_longin_1; First Longin domain of INTU, CCZ1 and HPS4
    pfam19032
    Location:553 → 671
    Intu_longin_2; Intu longin-like domain 2
    pfam19033
    Location:831 → 971
    Intu_longin_3; Intu longin-like domain 3

  4. XM_063281131.1 → XP_063137201.1  protein inturned isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4ACE5.1 GenPept UniProtKB/Swiss-Prot:D4ACE5

Gene LinkOut

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