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LOC108281134 SOX3 promoter region [ Homo sapiens (human) ]

Gene ID: 108281134, updated on 10-Oct-2023

Summary

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Gene symbol
LOC108281134
Gene description
SOX3 promoter region
Gene type
biological region
Feature type(s)
protein_bind
regulatory: promoter, response_element
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents the promoter of the SRY-box 3 (SOX3) gene. Activity of this promoter is stimulated by retinoic acid and binding by retinoid X receptor and nuclear transcription factor Y. It is negatively regulated by TGFB induced factor homeobox 1. [provided by RefSeq, Jul 2016]
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Genomic context

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See LOC108281134 in Genome Data Viewer
Location:
chromosome: X
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (140504802..140505510)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (138816689..138817397)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (139586967..139587675)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein S17 pseudogene 17 Neighboring gene uncharacterized LOC105373344 Neighboring gene NANOG hESC enhancer GRCh37_chrX:139608152-139608653 Neighboring gene SRY-box transcription factor 3 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:139655621-139655814 Neighboring gene uncharacterized LOC101928833

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of the SOX3 gene expression by retinoid receptors. Nikčević G, et al. Physiol Res, 2011. PMID 21777018
  2. Up-regulation of the SOX3 gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved. Nikcević G, et al. J Neurochem, 2008 Dec. PMID 18786169
  3. Functional characterization of the human SOX3 promoter: identification of transcription factors implicated in basal promoter activity. Kovacevic Grujicic N, et al. Gene, 2005 Jan 3. PMID 15656994
  4. Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. Kovacevic-Grujicic N, et al. BMB Rep, 2014 Apr. PMID 24257117, Free PMC Article
  5. TG-interacting factor (TGIF) downregulates SOX3 gene expression in the NT2/D1 cell line. Mojsin M, et al. J Genet Genomics, 2012 Jan. PMID 22293114

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051085.1 

    Range
    101..809
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    140504802..140505510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    138816689..138817397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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