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LOC108281125 SOX6 proximal promoter region [ Homo sapiens (human) ]

Gene ID: 108281125, updated on 10-Oct-2023

Summary

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Gene symbol
LOC108281125
Gene description
SOX6 proximal promoter region
Gene type
biological region
Feature type(s)
protein_bind
regulatory: promoter
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents the proximal promoter of the SRY-box 6 (SOX6) gene. This promoter is autoregulated by binding of SOX6 protein to a conserved element in this sequence. [provided by RefSeq, Jul 2016]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (16476371..16477487)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (16574191..16575307)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (16497918..16499034)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376572 Neighboring gene uncharacterized LOC124900593 Neighboring gene SRY-box transcription factor 6 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:16086747 Neighboring gene MPRA-validated peak1213 silencer Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:16133413 Neighboring gene MPRA-validated peak1214 silencer Neighboring gene VISTA enhancer hs1720 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:16199331 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:16200444 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:16210951 Neighboring gene VISTA enhancer hs883 Neighboring gene VISTA enhancer hs236 Neighboring gene VISTA enhancer hs717 Neighboring gene VISTA enhancer hs1301 Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 188, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells. Cantu' C, et al. Nucleic Acids Res, 2011 Jan. PMID 20852263, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051074.1 

    Range
    101..1217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    16476371..16477487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    16574191..16575307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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