LOC108178982 NEUROG3 upstream region homotypic clusters of transcription factor binding sites enhancer [Homo sapiens (human)] - Gene

Summary

Gene symbol: LOC108178982
Gene description: NEUROG3 upstream region homotypic clusters of transcription factor binding sites enhancer
Gene type: biological region
Feature type(s): misc_feature: conserved_region
regulatory: enhancer
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This genomic region is located approximately 2.5 kb upstream of the NEUROG3 (neurogenin 3) gene. It contains multiple homotypic clusters of transcription factor binding sites (HCTs) based on the presence of multiple binding motifs for NRF1 (nuclear respiratory factor 1) and E2F4 (E2F transcription factor 4). This HCT region was validated as an enhancer in transgenic reporter assays in mice. Another subregion was also validated as an enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells, where it is marked by the H3K4me1 histone modification. [provided by RefSeq, Jan 2023]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q21.3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (69575917..69579232)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (70443921..70447236)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (71335673..71338729)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

H3K4me1 hESC enhancer GRCh37_chr10:71338175-71338988
NRF1 and E2F4 HCT enhancer
VISTA enhancer hs1699

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.