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LOC108175347 Gcg promoter region [ Mus musculus (house mouse) ]

Gene ID: 108175347, updated on 9-Aug-2024

Summary

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Gene symbol
LOC108175347
Gene description
Gcg promoter region
Gene type
biological region
Feature type(s)
protein_bind
regulatory: promoter
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366692
Summary
This region represents the proximal promoter of the glucagon gene. Activity of this sequence may be stimulated by binding of paired box proteins and MAF bZIP transcription factor and downregulated by ALX homeobox 3. [provided by RefSeq, Jun 2016]
Orthologs
human all
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Genomic context

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See LOC108175347 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (62313954..62315442)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (62483610..62485098)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dipeptidylpeptidase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr2:62229877-62230177 Neighboring gene STARR-seq mESC enhancer starr_04638 Neighboring gene STARR-seq mESC enhancer starr_04639 Neighboring gene STARR-positive B cell enhancer ABC_E5925 Neighboring gene STARR-positive B cell enhancer ABC_E8786 Neighboring gene STARR-positive B cell enhancer ABC_E8787 Neighboring gene STARR-seq mESC enhancer starr_04641 Neighboring gene STARR-positive B cell enhancer ABC_E3379 Neighboring gene STARR-positive B cell enhancer ABC_E2037 Neighboring gene STARR-positive B cell enhancer ABC_E5926 Neighboring gene STARR-positive B cell enhancer ABC_E5927 Neighboring gene predicted gene 13561 Neighboring gene glucagon Neighboring gene fibroblast activation protein Neighboring gene STARR-seq mESC enhancer starr_04642 Neighboring gene interferon induced with helicase C domain 1 Neighboring gene predicted gene, 39839

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription. Lee YS, et al. Endocr J, 2014. PMID 24140652
  2. Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans. Sharma SK, et al. Biochem J, 2005 Aug 1. PMID 15828872, Free PMC Article
  3. Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter. Wang J, et al. J Biol Chem, 2003 Aug 29. PMID 12815047
  4. Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells. Mirasierra M, et al. Diabetologia, 2016 Apr. PMID 26739814
  5. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. Yi F, et al. J Biol Chem, 2005 Jan 14. PMID 15525634

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Other Names

  • regulatory region 366692

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050920.1 

    Range
    101..1589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    62313954..62315442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version