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FRS3 fibroblast growth factor receptor substrate 3 [ Homo sapiens (human) ]

Gene ID: 10817, updated on 5-Mar-2024

Summary

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Official Symbol
FRS3provided by HGNC
Official Full Name
fibroblast growth factor receptor substrate 3provided by HGNC
Primary source
HGNC:HGNC:16970
See related
Ensembl:ENSG00000137218 MIM:607744; AllianceGenome:HGNC:16970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNT2; FRS2B; SNT-2; FRS2beta; FRS2-beta
Summary
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
Expression
Broad expression in testis (RPKM 6.0), brain (RPKM 2.3) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
6p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41770176..41779900, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41598738..41608458, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41737914..41747638, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene transcription factor EB Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17190 Neighboring gene microRNA 10398 Neighboring gene progastricsin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41735161-41736013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17194 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41755120-41756119 Neighboring gene translocase of outer mitochondrial membrane 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding. Iejima D, et al. Oncogene, 2010 May 27. PMID 20228838
  2. Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. Huang L, et al. Oncogene, 2006 Oct 19. PMID 16702953
  3. Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras. Wang JK, et al. Oncogene, 1996 Aug 15. PMID 8761293
  4. SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. Huang L, et al. Biochem Biophys Res Commun, 2004 Nov 19. PMID 15485655
  5. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. Gotoh N, et al. FEBS Lett, 2004 Apr 23. PMID 15094036

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR family members and suggest a role for FRS2beta as a tumor suppressor.
    Title: FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding.
  2. an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings
    Title: Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
  4. SNT-2 negatively regulates ERK2 signaling activated via EGF stimulation through direct binding to ERK2
    Title: SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.
  5. FRS2beta can compensate for the loss of FRS2alpha for activation of MAP kinase when expressed in fibroblasts
    Title: FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.
  6. Novel mechanism of negative control of EGFR tyrosine kinase activity with SNT-2 by recruiting ERK2.
    Title: Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.
  7. FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors
    Title: FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC17167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
fibroblast growth factor receptor substrate 3
Names
FGFR substrate 3
FGFR-signaling adaptor SNT2
suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)
testicular tissue protein Li 71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006653.5 → NP_006644.1  fibroblast growth factor receptor substrate 3

    See identical proteins and their annotated locations for NP_006644.1

    Status: REVIEWED

    Source sequence(s)
    AF036718, HY036161
    Consensus CDS
    CCDS4860.1
    UniProtKB/Swiss-Prot
    O43559, Q5T3D5
    UniProtKB/TrEMBL
    A0A140VJJ7
    Related
    ENSP00000362109.3, ENST00000373018.7
    Conserved Domains (1) summary
    cd01202
    Location:15 → 106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    41770176..41779900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418097.1 → XP_047274053.1  fibroblast growth factor receptor substrate 3 isoform X1

    UniProtKB/Swiss-Prot
    O43559, Q5T3D5
    UniProtKB/TrEMBL
    A0A140VJJ7

  2. XM_011514254.2 → XP_011512556.1  fibroblast growth factor receptor substrate 3 isoform X1

    See identical proteins and their annotated locations for XP_011512556.1

    UniProtKB/Swiss-Prot
    O43559, Q5T3D5
    UniProtKB/TrEMBL
    A0A140VJJ7
    Conserved Domains (1) summary
    cd01202
    Location:15 → 106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    41598738..41608458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354066.1 → XP_054210041.1  fibroblast growth factor receptor substrate 3 isoform X1

    UniProtKB/Swiss-Prot
    O43559, Q5T3D5
    UniProtKB/TrEMBL
    A0A140VJJ7

  2. XM_054354067.1 → XP_054210042.1  fibroblast growth factor receptor substrate 3 isoform X1

    UniProtKB/Swiss-Prot
    O43559, Q5T3D5
    UniProtKB/TrEMBL
    A0A140VJJ7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43559.3 GenPept UniProtKB/Swiss-Prot:O43559

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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