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Ubxn8 UBX domain protein 8 [ Mus musculus (house mouse) ]

Gene ID: 108159, updated on 2-Nov-2024

Summary

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Official Symbol
Ubxn8provided by MGI
Official Full Name
UBX domain protein 8provided by MGI
Primary source
MGI:MGI:1337129
See related
Ensembl:ENSMUSG00000052906 AllianceGenome:MGI:1337129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rep-8; Rep8h; Ubxd6; D0H8S2298E
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in endoplasmic reticulum membrane; nucleolus; and nucleoplasm. Predicted to be active in endoplasmic reticulum and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human UBXN8 (UBX domain protein 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 11.6), placenta adult (RPKM 3.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ubxn8 in Genome Data Viewer
Location:
8 A4; 8 20.65 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34109614..34135515, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33619586..33645476, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 1, related sequence 17 Neighboring gene STARR-seq mESC enhancer starr_21108 Neighboring gene testis expressed gene 15 meiosis and synapsis associated Neighboring gene STARR-seq mESC enhancer starr_21109 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Neighboring gene STARR-positive B cell enhancer ABC_E4996 Neighboring gene STARR-seq mESC enhancer starr_21112 Neighboring gene predicted gene, 33433 Neighboring gene glutathione reductase Neighboring gene predicted gene, 24727

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structures of mouse Rep-8 cDNA and genomic clones. Yamabe Y, et al. Gene, 1999 Feb 4. PMID 9931425
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UBX domain-containing protein 8
Names
UBX domain containing 6
UBX domain-containing protein 6
protein Rep-8
reproduction 8 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178648.2 → NP_848763.2  UBX domain-containing protein 8

    See identical proteins and their annotated locations for NP_848763.2

    Status: VALIDATED

    Source sequence(s)
    AK132565, AK161397, BY613198
    Consensus CDS
    CCDS22234.1
    UniProtKB/Swiss-Prot
    Q9QZ49
    UniProtKB/TrEMBL
    Q3TTF2
    Related
    ENSMUSP00000092992.5, ENSMUST00000095349.6
    Conserved Domains (1) summary
    cl00155
    Location:192 → 271
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34109614..34135515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508980.5 → XP_006509043.1  UBX domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ49
    Conserved Domains (2) summary
    cd01774
    Location:150 → 225
    UBX_UBXN8; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 8 (UBXN8) and similar proteins
    pfam09751
    Location:67 → 171
    Es2; Nuclear protein Es2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ49.1 GenPept UniProtKB/Swiss-Prot:Q9QZ49

Gene LinkOut

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