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UTP14A UTP14A small subunit processome component [ Homo sapiens (human) ]

Gene ID: 10813, updated on 3-Apr-2024

Summary

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Official Symbol
UTP14Aprovided by HGNC
Official Full Name
UTP14A small subunit processome componentprovided by HGNC
Primary source
HGNC:HGNC:10665
See related
Ensembl:ENSG00000156697 MIM:300508; AllianceGenome:HGNC:10665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Utp14; NYCO16; SDCCAG16; dJ537K23.3
Summary
This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in lymph node (RPKM 5.9), appendix (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
Xq26.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (129906164..129929752)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (128224954..128248543)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129040140..129063728)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:128983483-128984298 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:128984299-128985112 Neighboring gene spalt like transcription factor 4 pseudogene 2 Neighboring gene uncharacterized LOC105373335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20984 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129086824-129087554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129093062-129093562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20985 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:129117440-129117676 Neighboring gene BCL6 corepressor like 1 Neighboring gene uncharacterized LOC124905216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129159157-129159656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20988 Neighboring gene Sharpr-MPRA regulatory region 15346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20989 Neighboring gene Sharpr-MPRA regulatory region 9263 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20994 Neighboring gene RAB33A, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of U three protein 14a (UTP14a) is associated with poor prognosis of esophageal squamous cell carcinoma. Li KK, et al. Thorac Cancer, 2019 Nov. PMID 31496055, Free PMC Article
  2. [Expression of hUTP14a in non-small cell lung cancer]. Zhang CF, et al. Beijing Da Xue Xue Bao Yi Xue Ban, 2019 Feb 18. PMID 30773559, Free PMC Article
  3. Human U3 protein 14a plays an anti-apoptotic role in cancer cells. Ma T, et al. Biol Chem, 2017 Oct 26. PMID 28672776
  4. Human U Three Protein 14a Expression is Increased in Hepatocellular Carcinoma and Associated with Poor Prognosis. Zhang JY, et al. Chin Med J (Engl), 2017 Feb 20. PMID 28218222, Free PMC Article
  5. Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer. Ren P, et al. Biochem Biophys Res Commun, 2019 May 14. PMID 30929921

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that UTP14a expression is correlated with tumor proliferation and invasion; higher expression of UTP14a is a predictor of poor prognosis in patients with esophageal squamous cell carcinoma (ESCC). Additionally, knockdown of UTP14a inhibits cell proliferation and invasion in ESCC cell line, ECA109.
    Title: Overexpression of U three protein 14a (UTP14a) is associated with poor prognosis of esophageal squamous cell carcinoma.
  2. UTP14a promotes angiogenesis through upregulating transcription and secretion of PDGFA in colorectal cancer.
    Title: Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer.
  3. hUTP14a interacts with c-Myc and protects c-Myc from ubiquitination and degradation in a USP36-dependent way.
    Title: Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc.
  4. suggesting that hUTP14a might possess a potential as a candidate marker for the early diagnosis screening of non-small cell lung cancer
    Title: [Expression of hUTP14a in non-small cell lung cancer].
  5. The hUTP14a protected tumor cells from chemotherapeutic drug-induced apoptosis and thus might possess a potential as a target for anti-tumor therapy.
    Title: Human U3 protein 14a plays an anti-apoptotic role in cancer cells.
  6. The positivity rate of hUTP14a expression was significantly higher in HCC specimens. Positive expression of nucleolar hUTP14a might act as a novel prognostic predictor for patients with HCC
    Title: Human U Three Protein 14a Expression is Increased in Hepatocellular Carcinoma and Associated with Poor Prognosis.
  7. hUTP14a physically interacts with p53 and functionally promotes p53 turn-over
    Title: A small ribosomal subunit (SSU) processome component, the human U3 protein 14A (hUTP14A) binds p53 and promotes p53 degradation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37089, KIAA0266

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
U3 small nucleolar RNA-associated protein 14 homolog A
Names
UTP14, U3 small nucleolar ribonucleoprotein, homolog A
UTP14A small subunit (SSU) processome component
antigen NY-CO-16
serologically defined colon cancer antigen 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166221.2 → NP_001159693.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK291918, AK298578, BQ017502, BU942896
    Consensus CDS
    CCDS55489.1
    UniProtKB/TrEMBL
    B4E343
    Related
    ENSP00000388669.2, ENST00000425117.6
    Conserved Domains (1) summary
    pfam04615
    Location:29 → 681
    Utp14; Utp14 protein

  2. NM_006649.4 → NP_006640.2  U3 small nucleolar RNA-associated protein 14 homolog A isoform 1

    See identical proteins and their annotated locations for NP_006640.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK291918, BQ017502
    Consensus CDS
    CCDS14615.1
    UniProtKB/Swiss-Prot
    A8K7A3, A8MVQ1, B4DQ08, E9PEL7, Q5JYF1, Q9BVJ6
    UniProtKB/TrEMBL
    B4E343
    Related
    ENSP00000377944.3, ENST00000394422.8
    Conserved Domains (1) summary
    pfam04615
    Location:29 → 733
    Utp14; Utp14 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    129906164..129929752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441790.1 → XP_047297746.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform X1

  2. XM_047441791.1 → XP_047297747.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    128224954..128248543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326402.1 → XP_054182377.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform X1

  2. XM_054326403.1 → XP_054182378.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BVJ6.1 GenPept UniProtKB/Swiss-Prot:Q9BVJ6

Gene LinkOut

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