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Slc22a7 solute carrier family 22 (organic anion transporter), member 7 [ Mus musculus (house mouse) ]

Gene ID: 108114, updated on 2-Nov-2024

Summary

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Official Symbol
Slc22a7provided by MGI
Official Full Name
solute carrier family 22 (organic anion transporter), member 7provided by MGI
Primary source
MGI:MGI:1859559
See related
Ensembl:ENSMUSG00000067144 AllianceGenome:MGI:1859559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NLT; OAT2
Summary
Enables alpha-ketoglutarate transmembrane transporter activity and prostaglandin transmembrane transporter activity. Involved in alpha-ketoglutarate transport; prostaglandin transport; and response to stilbenoid. Located in apical plasma membrane. Is expressed in metanephros. Orthologous to human SLC22A7 (solute carrier family 22 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward kidney adult (RPKM 85.4) See more
Orthologs
human all
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Genomic context

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See Slc22a7 in Genome Data Viewer
Location:
17 C; 17 22.9 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46743111..46749403, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46432185..46438477, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 318 Neighboring gene predicted gene 9706 Neighboring gene cysteine-rich protein 3 Neighboring gene predicted gene, 36541 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene tau tubulin kinase 1 Neighboring gene STARR-seq mESC enhancer starr_42667

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endoplasmic reticulum transporter OAT2 regulates drug metabolism and interaction. Arakawa H, et al. Biochem Pharmacol, 2024 Jul. PMID 38815630
  2. Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate. Islam R, et al. J Pharmacol Sci, 2008 Mar. PMID 18344607
  3. Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Kobayashi Y, et al. Mol Pharmacol, 2002 Jul. PMID 12065749
  4. Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones. Ljubojević M, et al. Am J Physiol Renal Physiol, 2007 Jan. PMID 16885152
  5. Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide. Kobayashi Y, et al. Eur J Pharmacol, 2005 Nov 7. PMID 16256982

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner.
    Title: Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate.
  2. there exists a sex- and species-related differential gene expression of the OAT2 isoform.
    Title: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice.
  3. OAT2 in mouse kidney exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation
    Title: Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones.
  4. Results indicate that mOAT2 plays a role for the transport of bumetanide on the luminal membranes of kidney proximal tubules.
    Title: Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC18877

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-ketoglutarate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-ketoglutarate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables prostaglandin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prostaglandin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in alpha-ketoglutarate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in alpha-ketoglutarate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within organic anion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in prostaglandin transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in prostaglandin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to stilbenoid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
solute carrier family 22 member 7
Names
mOAT2
organic anion transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144856.2 → NP_659105.2  solute carrier family 22 member 7

    See identical proteins and their annotated locations for NP_659105.2

    Status: VALIDATED

    Source sequence(s)
    AK082865, AK143949
    Consensus CDS
    CCDS28829.1
    UniProtKB/Swiss-Prot
    Q3UNX2, Q8BUQ9, Q8K4S9, Q8R0M7, Q8R125, Q91WU2
    UniProtKB/TrEMBL
    A0A0R4J122
    Related
    ENSMUSP00000084234.6, ENSMUST00000087012.7
    Conserved Domains (2) summary
    cd06174
    Location:146 → 511
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11 → 521
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46743111..46749403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WU2.1 GenPept UniProtKB/Swiss-Prot:Q91WU2

Gene LinkOut

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