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Lin7a lin-7 homolog A, crumbs cell polarity complex component [ Mus musculus (house mouse) ]

Gene ID: 108030, updated on 2-Nov-2024

Summary

Official Symbol
Lin7aprovided by MGI
Official Full Name
lin-7 homolog A, crumbs cell polarity complex componentprovided by MGI
Primary source
MGI:MGI:2135609
See related
Ensembl:ENSMUSG00000019906 AllianceGenome:MGI:2135609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Veli; Veli1; LIN-7A; MALS-1; TIP-33
Summary
Predicted to enable L27 domain binding activity; PDZ domain binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within inner ear development; neurotransmitter secretion; and synaptic vesicle transport. Located in basolateral plasma membrane. Is expressed in glans of male genital tubercle; lung; nervous system; paraxial mesenchyme; and sensory organ. Orthologous to human LIN7A (lin-7 homolog A, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 13.2), testis adult (RPKM 8.6) and 8 other tissues See more
Orthologs
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Genomic context

See Lin7a in Genome Data Viewer
Location:
10 D1; 10 55.83 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (107107410..107261007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (107271549..107425146)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24745 Neighboring gene predicted gene, 29674 Neighboring gene STARR-seq mESC enhancer starr_27782 Neighboring gene myogenic factor 5 Neighboring gene myogenic factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102231

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L27 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables L27 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic assembly at neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of MPP7-DLG1-LIN7 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in transport vesicle membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein lin-7 homolog A
Names
lin 7 homolog a
lin-7 homolog A
mammalian LIN-7 1
mammalian lin-seven protein 1
vertebrate homolog of C. elegans Lin-7 type 1
vertebrate lin-7 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033223.3NP_001028395.1  protein lin-7 homolog A isoform 2

    See identical proteins and their annotated locations for NP_001028395.1

    Status: VALIDATED

    Source sequence(s)
    AC116325, AC140338, AC155168
    Consensus CDS
    CCDS36050.1
    UniProtKB/TrEMBL
    Q3TUM0
    Related
    ENSMUSP00000100916.4, ENSMUST00000105280.5
    Conserved Domains (1) summary
    cd00992
    Location:265
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001039354.2NP_001034443.1  protein lin-7 homolog A isoform 1

    See identical proteins and their annotated locations for NP_001034443.1

    Status: VALIDATED

    Source sequence(s)
    AC116325, AC140338, AC155168
    Consensus CDS
    CCDS24160.1
    UniProtKB/Swiss-Prot
    Q8JZS0
    Related
    ENSMUSP00000020057.9, ENSMUST00000020057.16
    Conserved Domains (2) summary
    smart00569
    Location:3183
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd00992
    Location:106187
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001284329.2NP_001271258.1  protein lin-7 homolog A isoform 2

    See identical proteins and their annotated locations for NP_001271258.1

    Status: VALIDATED

    Source sequence(s)
    AC116325, AC140338, AC155168
    Consensus CDS
    CCDS36050.1
    UniProtKB/TrEMBL
    Q3TUM0
    Related
    ENSMUSP00000151715.2, ENSMUST00000218031.2
    Conserved Domains (1) summary
    cd00992
    Location:265
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    107107410..107261007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513031.4XP_006513094.1  protein lin-7 homolog A isoform X1

    Conserved Domains (2) summary
    cd00992
    Location:94175
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02672
    Location:3171
    L27; L27 domain
  2. XM_006513032.2XP_006513095.1  protein lin-7 homolog A isoform X2

    See identical proteins and their annotated locations for XP_006513095.1

    Conserved Domains (1) summary
    cd00992
    Location:35116
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_036155485.1XP_036011378.1  protein lin-7 homolog A isoform X3

    UniProtKB/TrEMBL
    Q3TUM0
    Conserved Domains (1) summary
    cd00992
    Location:265
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...