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CYSLTR1 cysteinyl leukotriene receptor 1 [ Homo sapiens (human) ]

Gene ID: 10800, updated on 11-Apr-2024

Summary

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Official Symbol
CYSLTR1provided by HGNC
Official Full Name
cysteinyl leukotriene receptor 1provided by HGNC
Primary source
HGNC:HGNC:17451
See related
Ensembl:ENSG00000173198 MIM:300201; AllianceGenome:HGNC:17451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYSLT1; CYSLTR; CYSLT1R; HMTMF81
Summary
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Broad expression in urinary bladder (RPKM 6.1), spleen (RPKM 5.2) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
Xq21.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (78271468..78327611, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (76708793..76764940, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77526965..77583108, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 3C, pseudogene Neighboring gene uncharacterized LOC107985669 Neighboring gene MPRA-validated peak7397 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29787 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:77769873-77770852 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 34 Neighboring gene UBE2V1 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children. Zhao M, et al. Eur Arch Otorhinolaryngol, 2021 Dec. PMID 33837837
  2. Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells. Koller A, et al. Sci Rep, 2020 Oct 19. PMID 33077798, Free PMC Article
  3. Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution. Rabinovitch N, et al. Epigenetics, 2021 Jan-Feb. PMID 32657253, Free PMC Article
  4. Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells. Satapathy SR, et al. Cancer Lett, 2020 Sep 28. PMID 32474153
  5. CysLT1R expression on ILC2s and effects of CysLT1R antagonist on ILC2 activity in patients with allergic rhinitis. Qin ZL, et al. Allergy, 2020 Apr. PMID 31732973

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
    Title: DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
  2. Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution.
    Title: Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution.
  3. The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children.
    Title: The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children.
  4. CysLT1R expression on ILC2s and effects of CysLT1R antagonist on ILC2 activity in patients with allergic rhinitis.
    Title: CysLT1R expression on ILC2s and effects of CysLT1R antagonist on ILC2 activity in patients with allergic rhinitis.
  5. Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells.
    Title: Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells.
  6. Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells.
    Title: Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells.
  7. Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.
    Title: Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.
  8. Drugs antagonizing the CysLT1 receptor, termed lukasts and typified by montelukast, are established therapeutics for clinical management of asthma.. Here we describe recent data indicating that montelukast may be used for prevention and treatment of AAA, thus representing a promising pharmacological tool for a deadly vascular disease with significant socio-economic impact.
    Title: Targeting cysteinyl-leukotrienes in abdominal aortic aneurysm.
  9. findings strongly implicate that cysLTR1 has the capacity to regulate cellular senescence in chondrocytes. It is suggested that montelukast may be a potential therapeutic agent for chondro-protective therapy.
    Title: Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes.
  10. The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children
    Title: Expression of cysteinyl leukotriene receptor 1 and 2 (CysLTR1 and CysLTR2) in the lymphocytes of hyperplastic tonsils: comparison between allergic and nonallergic snoring children.
Submit: New GeneRIF Correction See all GeneRIFs (68)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of cysteinyl leukotriene receptor 1 (CYSLTR1) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC46139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteinyl leukotriene receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in leukotriene signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
involved_in respiratory gaseous exchange by respiratory system TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cysteinyl leukotriene receptor 1
Names
G-protein coupled receptor HG55
LTD4 receptor
cysteinyl leukotriene D4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012809.1 RefSeqGene

    Range
    4980..61123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282186.2 → NP_001269115.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_001269115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131800, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
    Related
    ENSP00000478492.1, ENST00000614798.1
    Conserved Domains (2) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32 → 163
    7tm_4; Olfactory receptor

  2. NM_001282187.2 → NP_001269116.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_001269116.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131801, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
    Conserved Domains (2) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32 → 163
    7tm_4; Olfactory receptor

  3. NM_001282188.2 → NP_001269117.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_001269117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131802, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
    Conserved Domains (2) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32 → 163
    7tm_4; Olfactory receptor

  4. NM_006639.4 → NP_006630.1  cysteinyl leukotriene receptor 1

    See identical proteins and their annotated locations for NP_006630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AF133266, DQ131799, DQ131803
    Consensus CDS
    CCDS14439.1
    UniProtKB/Swiss-Prot
    B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
    Related
    ENSP00000362401.3, ENST00000373304.4
    Conserved Domains (2) summary
    pfam00001
    Location:40 → 295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:32 → 163
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    78271468..78327611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    76708793..76764940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y271.1 GenPept UniProtKB/Swiss-Prot:Q9Y271

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