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LOC107992387 heart enhancer 11 [ Homo sapiens (human) ]

Gene ID: 107992387, updated on 10-Oct-2023

Summary

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Gene symbol
LOC107992387
Gene description
heart enhancer 11
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region is located in an intron of the coronin 2B (CORO2B) gene. It was predicted to be a heart enhancer based on a classifier that assesses the presence and/or absence of various features implicated in heart development, including transcription factor binding sites. It was validated as a functional heart enhancer in a zebrafish in vivo reporter assay. [provided by RefSeq, Jun 2016]
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Genomic context

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Location:
15q23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (68700629..68700816)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66523208..66523393)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68992968..68993155)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370873 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:68799611-68800181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68810923-68811424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68811425-68811924 Neighboring gene coronin 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68842985-68843486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68871520-68872387 Neighboring gene Sharpr-MPRA regulatory region 3237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68882548-68883339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68892023-68892602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68893807-68894366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68900721-68901361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68906675-68907190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68933009-68933520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68933521-68934032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68934266-68934783 Neighboring gene uncharacterized LOC124903514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68943583-68944150 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:68944208-68944708 Neighboring gene Sharpr-MPRA regulatory region 8573 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68961677-68962176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68966278-68966778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68987247-68987836 Neighboring gene cysteinyl-tRNA synthetase 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69080134-69080641 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69083767-69084268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69084269-69084768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69087559-69088131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9650 Neighboring gene acidic nuclear phosphoprotein 32 family member A Neighboring gene microRNA 4312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide discovery of human heart enhancers. Narlikar L, et al. Genome Res, 2010 Mar. PMID 20075146, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050842.1 

    Range
    101..288
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    68700629..68700816
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    66523208..66523393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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