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LOC107963949 GHR downstream promoter region module B [ Homo sapiens (human) ]

Gene ID: 107963949, updated on 14-Mar-2024

Summary

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Gene symbol
LOC107963949
Gene description
GHR downstream promoter region module B
Gene type
biological region
Feature type(s)
protein_bind
regulatory: promoter, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents regulatory module B of the growth hormone receptor gene. It encompasses the downstream promoters for alternate 5' end transcript variants V1, V4, V7, and V8. This sequence includes hepatocyte nuclear factor 4 alpha recognition sites and GAGA sites, which recognize sequence specific transcription factors that positively and negatively regulate gene expression. [provided by RefSeq, May 2016]
Orthologs
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Genomic context

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Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (42546319..42550131)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (42801762..42805573)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (42546421..42550233)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2996 Neighboring gene NANOG hESC enhancer GRCh37_chr5:42225166-42225693 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85146 Neighboring gene NANOG hESC enhancer GRCh37_chr5:42288621-42289193 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85179 Neighboring gene GHR upstream promoter region module A Neighboring gene zinc finger protein 35 pseudogene Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42508817-42509317 Neighboring gene growth hormone receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42756975-42757476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42757477-42757976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42803834-42804334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42804335-42804835 Neighboring gene coiled-coil domain containing 152 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:42812153-42812718 Neighboring gene uncharacterized LOC124900970 Neighboring gene selenoprotein P

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a liver-specific promoter for the ovine growth hormone receptor. O'Mahoney JV, et al. Mol Cell Endocrinol, 1994 May. PMID 9397945
  2. Isolation of a liver-specific promoter for human growth hormone receptor gene. Zou L, et al. Endocrinology, 1997 Apr. PMID 9075743
  3. Variants of the 5'-untranslated sequence of human growth hormone receptor mRNA. Pekhletsky RI, et al. Mol Cell Endocrinol, 1992 Dec. PMID 1301391
  4. Human growth hormone receptor gene expression is regulated by Gfi-1/1b and GAGA cis-elements. Kenth G, et al. Mol Cell Endocrinol, 2011 Mar 30. PMID 21238539
  5. Organization and evolution of the human growth hormone receptor gene 5'-flanking region. Goodyer CG, et al. Endocrinology, 2001 May. PMID 11316758

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050657.1 

    Range
    101..3913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    42546319..42550131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    42801762..42805573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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