U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NES nestin [ Homo sapiens (human) ]

Gene ID: 10763, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
NESprovided by HGNC
Official Full Name
nestinprovided by HGNC
Primary source
HGNC:HGNC:7756
See related
Ensembl:ENSG00000132688 MIM:600915; AllianceGenome:HGNC:7756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nbla00170
Summary
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
Expression
Broad expression in heart (RPKM 67.0), fat (RPKM 29.0) and 17 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NES in Genome Data Viewer
Location:
1q23.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156668763..156677407, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155805165..155813809, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156638555..156647199, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene uncharacterized LOC101928177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156616142-156616665 Neighboring gene BCAN antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156624901-156625401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156626597-156627098 Neighboring gene brevican Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156627099-156627599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156628979-156629479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1433 Neighboring gene VISTA enhancer hs1891 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156636725-156637298 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156642834-156643494 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156643495-156644156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156645479-156646139 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156646801-156647461 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156661895-156662812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156674429-156674930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156676520-156677196 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156677875-156678551 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156682885-156683400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1434 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene methyltransferase like 25B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nestin expression in osteocytes following myeloablation and during bone marrow metastasis. Koerber RM, et al. Br J Haematol, 2023 Mar. PMID 36382360
  2. Nestin-dependent mitochondria-ER contacts define stem Leydig cell differentiation to attenuate male reproductive ageing. Yao S, et al. Nat Commun, 2022 Jul 11. PMID 35821241, Free PMC Article
  3. Is nestin a diagnostic marker for combined hepatocellular-cholangiocarcinoma? Sasaki M, et al. Histopathology, 2022 Apr. PMID 35076959
  4. Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells. Wang Q, et al. Mol Cancer Res, 2021 Oct. PMID 34158391, Free PMC Article
  5. Immunomorphology and molecular biology of mixed primary liver cancers: is Nestin a marker of intermediate-cell carcinoma? Malvi D, et al. Histopathology, 2020 Jan. PMID 31374137

See all (299) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of HIF-1alpha and Nestin in oral squamous cell carcinoma and its association with vasculogenic mimicry.
    Title: Expression of HIF-1α and Nestin in oral squamous cell carcinoma and its association with vasculogenic mimicry.
  2. Nestin expression in osteocytes following myeloablation and during bone marrow metastasis.
    Title: Nestin expression in osteocytes following myeloablation and during bone marrow metastasis.
  3. Expression of Markers Ki-67, Nestin, VEGF, CD34 and Apoptosis in Relatively Healthy Lung Tissue with Non-Changed and Metaplastic Bronchial Epithelium.
    Title: Expression of Markers Ki-67, Nestin, VEGF, CD34 and Apoptosis in Relatively Healthy Lung Tissue with Non-Changed and Metaplastic Bronchial Epithelium.
  4. Hyperglycemia affects neuronal differentiation and Nestin, FOXO1, and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem cells of children from diabetic mothers.
    Title: Hyperglycemia affects neuronal differentiation and Nestin, FOXO1, and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem cells of children from diabetic mothers.
  5. Nestin-dependent mitochondria-ER contacts define stem Leydig cell differentiation to attenuate male reproductive ageing.
    Title: Nestin-dependent mitochondria-ER contacts define stem Leydig cell differentiation to attenuate male reproductive ageing.
  6. Nestin and osteocrin mRNA increases in human semitendinosus myotendinous junction 7 days after a single bout of eccentric exercise.
    Title: Nestin and osteocrin mRNA increases in human semitendinosus myotendinous junction 7 days after a single bout of eccentric exercise.
  7. The relationship among integrin alpha 7, CD133 and Nestin as well as their correlation with clinicopathological features and prognosis in astrocytoma patients.
    Title: The relationship among integrin alpha 7, CD133 and Nestin as well as their correlation with clinicopathological features and prognosis in astrocytoma patients.
  8. Nestin promotes pulmonary fibrosis via facilitating recycling of TGF-beta receptor I.
    Title: Nestin promotes pulmonary fibrosis via facilitating recycling of TGF-β receptor I.
  9. Is nestin a diagnostic marker for combined hepatocellular-cholangiocarcinoma?
    Title: Is nestin a diagnostic marker for combined hepatocellular-cholangiocarcinoma?
  10. Spatial and temporal immunoreaction of nestin, CD44, collagen IX and GFAP in human retinal Muller cells in the developing fetal eye.
    Title: Spatial and temporal immunoreaction of nestin, CD44, collagen IX and GFAP in human retinal Müller cells in the developing fetal eye.
Submit: New GeneRIF Correction See all GeneRIFs (219)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ21841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CCR5 chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intermediate filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell projection morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in embryonic camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of intermediate filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of intermediate filament depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament NAS
Non-traceable Author Statement
more info
 PubMed 
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nestin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012300.1 RefSeqGene

    Range
    4991..13635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006617.2 → NP_006608.1  nestin

    See identical proteins and their annotated locations for NP_006608.1

    Status: REVIEWED

    Source sequence(s)
    AK025494, AL590666, BC051373
    Consensus CDS
    CCDS1151.1
    UniProtKB/Swiss-Prot
    O00552, P48681, Q3LIF5, Q5SYZ6
    Related
    ENSP00000357206.3, ENST00000368223.4
    Conserved Domains (1) summary
    pfam00038
    Location:7 → 312
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156668763..156677407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155805165..155813809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024609.1: Suppressed sequence

    Description
    NM_024609.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48681.2 GenPept UniProtKB/Swiss-Prot:P48681

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous