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LOC107457602 meiotic recombination hotspot R [ Homo sapiens (human) ]

Gene ID: 107457602, updated on 10-Oct-2023

Summary

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Gene symbol
LOC107457602
Gene description
meiotic recombination hotspot R
Gene type
biological region
Feature type(s)
misc_recomb: meiotic
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region has been identified as a meiotic recombination hotspot by sperm typing assays, molecular assays in male germ cells to identify meiotic double strand breaks, and linkage disequilibrium studies. Meiotic hotspot activity can vary widely amongst individuals and can be influenced by both the nucleotide sequence at the meiotic recombination hotspot and the specific alleles present at the PR domain 9 (PRDM9) locus. [provided by RefSeq, Mar 2016]
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Genomic context

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See LOC107457602 in Genome Data Viewer
Location:
20p13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (5231829..5235507)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (5271236..5274914)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5212475..5216153)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:5107325-5107826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5113215-5113716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5113717-5114216 Neighboring gene proliferating cell nuclear antigen Neighboring gene CDP-diacylglycerol synthase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5150939-5151438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17515 Neighboring gene Sharpr-MPRA regulatory region 2649 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:5156307-5156942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17517 Neighboring gene OCT4 hESC enhancer GRCh37_chr20:5246300-5246801 Neighboring gene ubiquitin conjugating enzyme E2 D3 pseudogene 1 Neighboring gene prokineticin receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sperm cross-over activity in regions of the human genome showing extreme breakdown of marker association. Webb AJ, et al. Proc Natl Acad Sci U S A, 2008 Jul 29. PMID 18650392, Free PMC Article
  2. Fine-scale recombination rate differences between sexes, populations and individuals. Kong A, et al. Nature, 2010 Oct 28. PMID 20981099
  3. DNA recombination. Recombination initiation maps of individual human genomes. Pratto F, et al. Science, 2014 Nov 14. PMID 25395542, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046841.1 

    Range
    101..3779
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    5231829..5235507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    5271236..5274914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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