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LOC107275221 origin of replication in RNF185 [ Homo sapiens (human) ]

Gene ID: 107275221, updated on 10-Oct-2023

Summary

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Gene symbol
LOC107275221
Gene description
origin of replication in RNF185
Gene type
biological region
Feature type(s)
rep_origin
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region contains an origin of DNA replication consisting of multiple peaks of nascent strand synthesis. This sequence replicates late in S phase and associates with origin recognition complex subunit 6 and minichromosome maintenance complex component 5. [provided by RefSeq, Feb 2016]
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Genomic context

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Location:
22q12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (31194235..31196224)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31657793..31659782)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31590221..31592210)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9733 Neighboring gene SNRPN pseudogene 2 Neighboring gene microRNA 3928 Neighboring gene ring finger protein 185 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:31579617-31580130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:31580131-31580643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31608967-31609892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18850 Neighboring gene LIM domain kinase 2 Neighboring gene RNA, U6 small nuclear 1128, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31643479-31644369 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31644370-31645259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31672194-31672774 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impaired replication dynamics at the FRA3B common fragile site. Palakodeti A, et al. Hum Mol Genet, 2010 Jan 1. PMID 19815620, Free PMC Article
  2. High-throughput mapping of origins of replication in human cells. Lucas I, et al. EMBO Rep, 2007 Aug. PMID 17668008, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046743.1 

    Range
    101..2090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    31194235..31196224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    31657793..31659782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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