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OGA O-GlcNAcase [ Homo sapiens (human) ]

Gene ID: 10724, updated on 7-Apr-2024

Summary

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Official Symbol
OGAprovided by HGNC
Official Full Name
O-GlcNAcaseprovided by HGNC
Primary source
HGNC:HGNC:7056
See related
Ensembl:ENSG00000198408 MIM:604039; AllianceGenome:HGNC:7056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEA5; MGEA5; NCOAT
Summary
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 42.8), lymph node (RPKM 37.2) and 25 other tissues See more
Orthologs
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Genomic context

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See OGA in Genome Data Viewer
Location:
10q24.32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101784450..101818444, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102667945..102701933, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103544207..103578201, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103529890-103530667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534038-103534776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534777-103535515 Neighboring gene FGF8 5' regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103542131-103542770 Neighboring gene fibroblast growth factor 8 Neighboring gene nucleophosmin/nucleoplasmin 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103577734-103578309 Neighboring gene Sharpr-MPRA regulatory region 4495 Neighboring gene KCNIP2 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103587343-103588542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103590597-103591113 Neighboring gene Sharpr-MPRA regulatory region 3638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103596213-103596713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103603069-103603574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2734 Neighboring gene potassium voltage-gated channel interacting protein 2 Neighboring gene uncharacterized LOC101927445 Neighboring gene armadillo like helical domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair. Cui Y, et al. Cell Death Dis, 2021 Jun 16. PMID 34135314, Free PMC Article
  2. Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils. Tavassoly O, et al. FEBS J, 2021 Jan. PMID 32365408
  3. Proteomic analysis of the OGT interactome: novel links to epithelial-mesenchymal transition and metastasis of cervical cancer. Gao J, et al. Carcinogenesis, 2018 Oct 8. PMID 30052810, Free PMC Article
  4. Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. Li B, et al. Nat Commun, 2017 Sep 22. PMID 28939839, Free PMC Article
  5. The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels. De Leon CA, et al. Biochemistry, 2017 Jul 11. PMID 28627871, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.
    Title: Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.
  2. Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling.
    Title: Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling.
  3. Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.
    Title: Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.
  4. OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
    Title: OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
  5. Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of alpha-synuclein preformed fibrils.
    Title: Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils.
  6. Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.
    Title: Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.
  7. Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
    Title: Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
  8. Study reports that OGA is upregulated in a wide range of human cancers and drives aerobic glycolysis and tumor growth by inhibiting pyruvate kinase M2 (PKM2). PKM2 is dynamically O-GlcNAcylated in response to changes in glucose availability. Under high glucose conditions, PKM2 is a target of OGA-associated acetyltransferase activity, which facilitates O-GlcNAcylation of PKM2 by O-GlcNAc transferase (OGT).
    Title: O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.
  9. role of the tubular biomarkers NAG, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in patients with chest pain before contrast media exposition
    Title: The role of the tubular biomarkers NAG, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in patients with chest pain before contrast media exposition.
  10. OGT promotes carcinogenesis and metastasis of cervical cancer cells. OGT's expression is significantly upregulated in cervical cancer, and low OGT level is correlated with improved prognosis
    Title: Proteomic analysis of the OGT interactome: novel links to epithelial-mesenchymal transition and metastasis of cervical cancer.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11229, FLJ23355, KIAA0679

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-N-acetylglucosaminidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-N-acetylglucosaminidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hyalurononglucosaminidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycoprotein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in glycoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein deglycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein O-GlcNAcase
Names
N-acetyl-beta-D-glucosaminidase
N-acetyl-beta-glucosaminidase
beta-N-acetylglucosaminidase
beta-N-acetylhexosaminidase
beta-hexosaminidase
bifunctional protein NCOAT
hyaluronidase in meningioma
meningioma expressed antigen 5 (hyaluronidase)
meningioma-expressed antigen 5
nuclear cytoplasmic O-GlcNAcase and acetyltransferase
NP_001135906.1
NP_036347.1
XP_047280470.1
XP_047280471.1
XP_047280472.1
XP_047280473.1
XP_047280474.1
XP_054220599.1
XP_054220600.1
XP_054220601.1
XP_054220602.1
XP_054220603.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142434.2 → NP_001135906.1  protein O-GlcNAcase isoform b

    See identical proteins and their annotated locations for NP_001135906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC010789
    Consensus CDS
    CCDS44471.1
    UniProtKB/Swiss-Prot
    O60502
    Related
    ENSP00000409973.1, ENST00000439817.5
    Conserved Domains (1) summary
    pfam07555
    Location:62 → 338
    NAGidase; beta-N-acetylglucosaminidase

  2. NM_012215.5 → NP_036347.1  protein O-GlcNAcase isoform a

    See identical proteins and their annotated locations for NP_036347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC010789
    Consensus CDS
    CCDS7520.1
    UniProtKB/Swiss-Prot
    B7WPB9, D3DR79, E9PGF9, O60502, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0
    Related
    ENSP00000354850.3, ENST00000361464.8
    Conserved Domains (1) summary
    pfam07555
    Location:62 → 338
    NAGidase; beta-N-acetylglucosaminidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    101784450..101818444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424515.1 → XP_047280471.1  protein O-GlcNAcase isoform X2

  2. XM_047424514.1 → XP_047280470.1  protein O-GlcNAcase isoform X1

  3. XM_047424516.1 → XP_047280472.1  protein O-GlcNAcase isoform X3

  4. XM_047424518.1 → XP_047280474.1  protein O-GlcNAcase isoform X5

    Related
    ENSP00000359112.3, ENST00000370094.7

  5. XM_047424517.1 → XP_047280473.1  protein O-GlcNAcase isoform X4

RNA

  1. XR_007061939.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    102667945..102701933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364625.1 → XP_054220600.1  protein O-GlcNAcase isoform X2

  2. XM_054364624.1 → XP_054220599.1  protein O-GlcNAcase isoform X1

  3. XM_054364626.1 → XP_054220601.1  protein O-GlcNAcase isoform X3

  4. XM_054364628.1 → XP_054220603.1  protein O-GlcNAcase isoform X5

  5. XM_054364627.1 → XP_054220602.1  protein O-GlcNAcase isoform X4

RNA

  1. XR_008488157.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60502.2 GenPept UniProtKB/Swiss-Prot:O60502

Gene LinkOut

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