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Cbl E3 ubiquitin-protein ligase CBL [ Neodiprion lecontei (redheaded pine sawfly) ]

Gene ID: 107225234, updated on 1-Oct-2024

Summary

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Gene symbol
Cbl
Gene description
E3 ubiquitin-protein ligase CBL
See related
EnsemblRapid:ENSNLCG00000009496 EnsemblRapid:ENSNLCG00000011197
Gene type
protein coding
RefSeq status
MODEL
Organism
Neodiprion lecontei
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Tenthredinoidea; Diprionidae; Diprioninae; Neodiprion
Orthologs
honey bee all
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Genomic context

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See Cbl in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
101 current iyNeoLeco1.1 (GCF_021901455.1) 5 NC_060264.1 (25993581..26026710, complement)
100 previous assembly Nlec1.0 (GCF_001263575.1) Unplaced Scaffold NW_015381150.1 (89350..119515, complement)

Chromosome 5 - NC_060264.1Genomic Context describing neighboring genes Neighboring gene ras GTPase-activating-like protein IQGAP1 Neighboring gene uncharacterized LOC124294596 Neighboring gene uncharacterized LOC107225167 Neighboring gene peroxin 6 Neighboring gene glutathione peroxidase-like 1 Neighboring gene Glycerol kinase 2 Neighboring gene uncharacterized LOC107225137

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL; E3 ubiquitin-protein ligase CBL-B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Neodiprion lecontei Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference iyNeoLeco1.1

Genomic

  1. NC_060264.1 Reference iyNeoLeco1.1

    Range
    25993581..26026710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046740509.1 → XP_046596465.1  E3 ubiquitin-protein ligase CBL-B isoform X2

  2. XM_015665638.2 → XP_015521124.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    A0A6J0C403
    Related
    ENSNLCP00000017759.1, ENSNLCT00000020296.1
    Conserved Domains (5) summary
    cd09920
    Location:241 → 337
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14318
    Location:665 → 704
    UBA_Cbl_like; UBA domain found in casitas B-lineage lymphoma (Cbl) proteins
    pfam02262
    Location:38 → 159
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:163 → 246
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    pfam13920
    Location:364 → 412
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  3. XM_015665645.2 → XP_015521131.1  E3 ubiquitin-protein ligase CBL isoform X3

    UniProtKB/TrEMBL
    A0A6J0C1J2
    Related
    ENSNLCP00000020721.1, ENSNLCT00000023889.1
    Conserved Domains (4) summary
    cd09920
    Location:241 → 337
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02262
    Location:38 → 159
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:163 → 246
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    pfam13920
    Location:364 → 412
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein
Heading Accession and Version

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