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UGT2B11 UDP glucuronosyltransferase family 2 member B11 [ Homo sapiens (human) ]

Gene ID: 10720, updated on 23-Nov-2023

Summary

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Official Symbol
UGT2B11provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member B11provided by HGNC
Primary source
HGNC:HGNC:12545
See related
Ensembl:ENSG00000213759 MIM:603064; AllianceGenome:HGNC:12545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables glucuronosyltransferase activity. Involved in estrogen metabolic process and xenobiotic glucuronidation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver (RPKM 8.5), gall bladder (RPKM 8.1) and 2 other tissues See more
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Genomic context

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See UGT2B11 in Genome Data Viewer
Location:
4q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69199951..69224984, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (72640420..72668386, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70065669..70080466, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP-glucuronosyltransferase 2A1-like Neighboring gene MPRA-validated peak5051 silencer Neighboring gene uncharacterized LOC105377267 Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B4 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11. Beaulieu M, et al. Biochem Biophys Res Commun, 1998 Jul 9. PMID 9675083
  2. Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study. Ohno S, et al. Drug Metab Lett, 2011 Aug. PMID 21679149
  3. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Jin CJ, et al. Biochem Biophys Res Commun, 1993 Jul 15. PMID 8333863
  4. Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays. Li XΑ, et al. Mol Med Rep, 2015 Oct. PMID 26238215, Free PMC Article
  5. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. Li J, et al. Breast Cancer Res, 2010. PMID 20214802, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CYP3A4, CYP3A7, UGT2B11 and UGT2B15 genes are significantly downregulated in melanosis coli.
    Title: Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.
  2. significant expression of UGT2B11 was detected in the liver, breast and kidney, and was clearly different from the distribution of UGT2B28
    Title: Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129611, MGC129612

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in estrogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in estrogen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic glucuronidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-glucuronosyltransferase 2B11
Names
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glycosyltransferase 2 family protein
UDP glycosyltransferase 2 family, polypeptide B11
UDPGT 2B11
NP_001064.1
XP_011529852.1
XP_016863149.1
XP_047305499.1
XP_054204768.1
XP_054204769.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001073.3 → NP_001064.1  UDP-glucuronosyltransferase 2B11 precursor

    See identical proteins and their annotated locations for NP_001064.1

    Status: VALIDATED

    Source sequence(s)
    AC111000, AC114797, AF016492, BG184936
    Consensus CDS
    CCDS3527.1
    UniProtKB/Swiss-Prot
    O75310, Q3KNV9
    Related
    ENSP00000387683.1, ENST00000446444.2
    Conserved Domains (1) summary
    pfam00201
    Location:24 → 525
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    69199951..69224984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007660.3 → XP_016863149.1  UDP-glucuronosyltransferase 2B11 isoform X2

  2. XM_047449543.1 → XP_047305499.1  UDP-glucuronosyltransferase 2B11 isoform X2

  3. XM_011531550.3 → XP_011529852.1  UDP-glucuronosyltransferase 2B11 isoform X1

    Conserved Domains (2) summary
    PHA03392
    Location:185 → 423
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:24 → 441
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    72640420..72668386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348794.1 → XP_054204769.1  UDP-glucuronosyltransferase 2B11 isoform X2

  2. XM_054348793.1 → XP_054204768.1  UDP-glucuronosyltransferase 2B11 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75310.1 GenPept UniProtKB/Swiss-Prot:O75310

Gene LinkOut

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