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IL4 interleukin 4 [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 107130068, updated on 1-Aug-2024

Summary

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Gene symbol
IL4
Gene description
interleukin 4
See related
Ensembl:ENSMFAG00000002906
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
BSF-1
Orthologs
human mouse all
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Genomic context

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See IL4 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 6 NC_088380.1 (139197299..139206257)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 6 NC_052260.1 (127829667..127838204)

Chromosome 6 - NC_088380.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC135971147 Neighboring gene interleukin 13 Neighboring gene kinesin family member 3A Neighboring gene cyclin I family member 2 Neighboring gene septin 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-4 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell costimulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in activation of Janus kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response in mucosa IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in microglial cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in myeloid dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of T-helper 17 cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of complement-dependent cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MHC class II biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of eosinophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of isotype switching to IgE isotypes IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mononuclear cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-4
Names
B-cell stimulatory factor 1
IL-4
Interleukin-4
Lymphocyte stimulatory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088380.1 Reference T2T-MFA8v1.0

    Range
    139197299..139206257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045394210.2 → XP_045250145.2  interleukin-4

    UniProtKB/TrEMBL
    A0A2K5W6N4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79339.2 GenPept UniProtKB/Swiss-Prot:P79339

Gene LinkOut

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