CD2-LCR CD2 locus control region [Homo sapiens (human)] - Gene

Summary

Gene symbol: CD2-LCR
Gene description: CD2 locus control region
Gene type: biological region
Feature type(s): protein_bind
regulatory: DNase_I_hypersensitive_site, enhancer, locus_control_region, transcriptional_cis_regulatory_region
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD2-DCR
Summary: This element represents a locus control region (LCR) that can confer T cell-specific, copy number-dependent, position-independent expression on the CD2 gene in transgenic mice. It is located immediately downstream of the 3' terminal exon of the CD2 gene, and is characterized by three DNase I hypersensitive sites and a core enhancer region. This LCR and the enhancer sub-region have been used to drive T cell-specific expression of several heterologous genes in various vector systems, including retroviral and lentiviral vectors. A truncated version of the LCR has been shown to be heterochromatin-sensitive, and has thus been useful for studying chromatin-related processes, such as triplet-repeat-associated position effect variegation. [provided by RefSeq, Jan 2016]
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Genomic context

Location:: 1p13.1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (116769217..116774826)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (116779660..116785269)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (117311839..117317448)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

CD2 T-cell-specific enhancer
CD2 dominant control region
CD2 lymphoctye-specific enhancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.