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LOC107126281 NUP98-HOXA11 recombination region [ Homo sapiens (human) ]

Gene ID: 107126281, updated on 10-Oct-2023

Summary

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Gene symbol
LOC107126281
Gene description
NUP98-HOXA11 recombination region
Gene type
biological region
Feature type(s)
misc_recomb: mitotic
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region is known to undergo somatic cell DNA recombination with another region, the nucleoporin 98kDa (NUP98) recombination region, located on the p arm of chromosome 11. Recombination between these two regions results in a translocation known as the t(7;11)(p15;p15) rearrangement, and can produce in-frame gene fusions involving the nucleoporin 98kDa (NUP98) gene and the homeobox A11 (HOXA11) gene. The NUP98-HOXA11 fusion transcripts have been observed in some individuals with chronic myeloid leukemia (CML) and juvenile myelomonocytic leukemia (JMML). [provided by RefSeq, Mar 2017]
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Genomic context

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See LOC107126281 in Genome Data Viewer
Location:
7p15.2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (27183029..27185218)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (27319037..27321226)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27222648..27224837)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HOXA10-HOXA9 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27208794-27209384 Neighboring gene HOXA10 antisense RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27211139-27211638 Neighboring gene microRNA 196b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27213347-27213993 Neighboring gene homeobox A10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27213994-27214639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27218758-27219360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27219361-27219962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27222450-27223332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27223333-27224214 Neighboring gene homeobox A11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27225097-27225978 Neighboring gene HOXA11 antisense RNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27231749-27232306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27232307-27232864 Neighboring gene homeobox A13 Neighboring gene NUP98-HOXA13 recombination region

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Juvenile myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98-HOXA11 fusion. Mizoguchi Y, et al. Am J Hematol, 2009 May. PMID 19338047
  2. t(7;11)(p15;p15) Chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion. Suzuki A, et al. Br J Haematol, 2002 Jan. PMID 11841413
  3. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Wang GG, et al. Nature, 2009 Jun 11. PMID 19430464, Free PMC Article
  4. Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). Fujino T, et al. Blood, 2002 Feb 15. PMID 11830496
  5. NUP98 gene fusions in hematologic malignancies. Lam DH, et al. Leukemia, 2001 Nov. PMID 11681408

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • t(7;11)(p15;p15) HOXA11 recombination region
  • t(7;11)(p15;p15) homeobox A11 recombination region

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046616.1 

    Range
    101..2290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    27183029..27185218
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    27319037..27321226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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