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LOC107063610 origin of replication in promoter of HSPA1A [ Homo sapiens (human) ]

Gene ID: 107063610, updated on 10-Oct-2023

Summary

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Gene symbol
LOC107063610
Gene description
origin of replication in promoter of HSPA1A
Gene type
biological region
Feature type(s)
protein_bind
rep_origin
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region contains an origin of DNA replication located in the promoter of the heat shock protein family A (Hsp70) member 1A (HSPA1A) gene. Activity of this sequence in promoting replication may require binding by v-myc avian myelocytomatosis viral oncogene homolog to two recognition sites. [provided by RefSeq, Jan 2016]
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Genomic context

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See LOC107063610 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (31815250..31815907)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (31668307..31668964)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31783027..31783684)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene valyl-tRNA synthetase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:31759127-31759287 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:31759783-31760982 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31763127-31763981 Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31782423-31783252 Neighboring gene heat shock protein family A (Hsp70) member 1 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31783959-31784528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31784529-31785098 Neighboring gene heat shock protein family A (Hsp70) member 1A Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:31789548-31790747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31794443-31795254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31795278-31795907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31795908-31796536 Neighboring gene heat shock protein family A (Hsp70) member 1B Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31801830-31802528 Neighboring gene small nucleolar RNA, C/D box 48 Neighboring gene small nucleolar RNA host gene 32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel DNA replication origin identified in the human heat shock protein 70 gene promoter. Taira T, et al. Mol Cell Biol, 1994 Sep. PMID 8065368, Free PMC Article
  2. c-myc protein complex binds to two sites in human hsp70 promoter region. Taira T, et al. Biochim Biophys Acta, 1992 Mar 24. PMID 1562593
  3. Differential DNA replication origin activities in human normal skin fibroblast and HeLa cell lines. Tao L, et al. J Mol Biol, 1997 Oct 31. PMID 9356241

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046363.1 

    Range
    101..758
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    31815250..31815907
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    3147872..3148529
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    3292501..3293158
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    3063029..3063686
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    3071078..3071735
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    31668307..31668964
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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