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Lars1 leucyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 107045, updated on 2-Nov-2024

Summary

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Official Symbol
Lars1provided by MGI
Official Full Name
leucyl-tRNA synthetase 1provided by MGI
Primary source
MGI:MGI:1913808
See related
Ensembl:ENSMUSG00000024493 AllianceGenome:MGI:1913808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lars; leuRS; 2310045K21Rik; 3110009L02Rik
Summary
Enables leucine-tRNA ligase activity. Involved in leucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.9), placenta adult (RPKM 10.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lars1 in Genome Data Viewer
Location:
18 B3; 18 22.37 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (42335363..42395302, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (42202298..42262237, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene PLAC8-like 1 Neighboring gene predicted gene, 18086 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_44434 Neighboring gene ribosomal protein S19, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E494 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:42434622-42434731 Neighboring gene STARR-positive B cell enhancer ABC_E495 Neighboring gene predicted gene 4013 Neighboring gene RNA binding motif protein 27 Neighboring gene STARR-seq mESC enhancer starr_44436

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy. You JS, et al. Am J Pathol, 2024 Aug. PMID 38762116,
  2. Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration. Son K, et al. J Clin Invest, 2019 Apr 15. PMID 30985292, Free PMC Article
  3. Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics. Passarelli MC, et al. Nat Cell Biol, 2022 Mar. PMID 35288656, Free PMC Article
  4. Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1. Yoon I, et al. Science, 2020 Jan 10. PMID 31780625
  5. Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways. Li B, et al. Life Sci, 2019 May 1. PMID 30905780

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy.
    Title: Leucyl-tRNA Synthetase Contributes to Muscle Weakness through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy.
  2. this study provides evidence for a role of leucyl-tRNA synthetase 1 (LARS1) in glucose-dependent control of leucine usage
    Title: Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.
  3. leucyl-tRNA synthetase has a nontranslational function in regulating myogenic differentiation and skeletal muscle regeneration
    Title: Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration.
  4. High LARS expression is associated with abdominal aortic aneurysm.
    Title: Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1352

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA editing activity ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA editing activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutamine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables leucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leucine-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables leucine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables leucine-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to L-leucine IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to L-leucine ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to leucine starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in glutaminyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in glutaminyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in leucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leucyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in leucyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell size IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine--tRNA ligase, cytoplasmic
Names
leucyl-tRNA synthetase, cytoplasmic
NP_598898.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134137.3 → NP_598898.2  leucine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_598898.2

    Status: VALIDATED

    Source sequence(s)
    BB652360, BC052715, BE989557
    Consensus CDS
    CCDS37796.1
    UniProtKB/Swiss-Prot
    Q8BKW9, Q8BMJ2
    UniProtKB/TrEMBL
    Q6ZPT2, Q7TSZ3
    Related
    ENSMUSP00000095197.4, ENSMUST00000097590.5
    Conserved Domains (5) summary
    cd07959
    Location:757 → 876
    Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
    cd00812
    Location:527 → 759
    LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
    PLN02959
    Location:3 → 1064
    PLN02959; aminoacyl-tRNA ligase
    cl00015
    Location:47 → 231
    nt_trans; nucleotidyl transferase superfamily
    cl12020
    Location:858 → 907
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    42335363..42395302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001782319.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMJ2.2 GenPept UniProtKB/Swiss-Prot:Q8BMJ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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