CETN3 centrin 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CETN3provided by HGNC
Official Full Name: centrin 3provided by HGNC
Primary source: HGNC:HGNC:1868
See related: Ensembl:ENSG00000153140 MIM:602907; AllianceGenome:HGNC:1868
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CEN3; CDC31
Summary: The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression: Broad expression in testis (RPKM 62.8), adrenal (RPKM 10.5) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q14.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (90392257..90409756, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (90878812..90896306, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (89688074..89705573, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cetn3 inhibits Mps1 autophosphorylation at Thr-676, a known site of T-loop autoactivation, and interferes with Mps1-dependent phosphorylation of Cetn2. The cellular overexpression of Cetn3 attenuates the incorporation of Cetn2 into centrioles and centrosome reduplication, whereas depletion of Cetn3 generates extra centrioles.
Title: Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function.
Observational study of gene-disease association. (HuGE Navigator)
Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
could be classified as a Ca(2+) sensor protein
Title: Calcium and magnesium binding to human centrin 3 and interaction with target peptides.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Studies using a combined approach of immunofluorescence detection of Gag protein and in situ hybridization detection of viral genomic RNA indicate Gag co-localizes with Psi+ RNA in the perinuclear region and also co-localizes with centrins	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93659 (e-PCR)
- UniSTS:89161

NoName (e-PCR)
- UniSTS:483050

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	TAS Traceable Author Statement more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in photoreceptor connecting cilium	IEA Inferred from Electronic Annotation more info
part_of transcription export complex 2	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: centrin-3

Names: CDC31 yeast homolog; EF-hand superfamily member; centrin, EF-hand protein, 3 (CDC31 homolog, yeast)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001297765.2 → NP_001284694.1 centrin-3 isoform 1

See identical proteins and their annotated locations for NP_001284694.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC093510, BM553126, BQ000279, CB998764

Consensus CDS

CCDS75274.1

UniProtKB/TrEMBL

E5RJF8, Q6ICP7

Related

ENSP00000428259.1, ENST00000522083.5

Conserved Domains (1) summary

PTZ00183
Location:15 → 190

PTZ00183; centrin; Provisional
NM_001297768.2 → NP_001284697.1 centrin-3 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate splice site in the 3' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC093510, BC093793, BQ000279, BU569574, CB998764

Consensus CDS

CCDS78036.1

UniProtKB/TrEMBL

E5RFM2

Related

ENSP00000430361.1, ENST00000522864.5

Conserved Domains (1) summary

PTZ00183
Location:15 → 115

PTZ00183; centrin; Provisional
NM_004365.4 → NP_004356.2 centrin-3 isoform 2

See identical proteins and their annotated locations for NP_004356.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC093510, BC005383, BQ000279, CB998764

Consensus CDS

CCDS4066.1

UniProtKB/Swiss-Prot

O15182, Q53YD2, Q9BS23

UniProtKB/TrEMBL

Q6ICP7

Related

ENSP00000283122.3, ENST00000283122.8

Conserved Domains (1) summary

PTZ00183
Location:15 → 166

PTZ00183; centrin; Provisional